ID   CR1CB_BACTG             Reviewed;        1176 AA.
AC   P56953;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Pesticidal crystal protein Cry1Cb;
DE   AltName: Full=133 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIC(b);
GN   Name=cry1Cb; Synonyms=cryIC(b);
OS   Bacillus thuringiensis subsp. galleriae.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=29338;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HD-29;
RX   PubMed=8476286; DOI=10.1128/aem.59.4.1131-1137.1993;
RA   Kalman S.S.;
RT   "Cloning a novel cryIC-type gene from a strain of Bacillus thuringiensis
RT   galleriae.";
RL   Appl. Environ. Microbiol. 59:1131-1137(1993).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects. Toxic to Spodoptera exigua and
CC       Trichoplusia ni.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; M97880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A48970; A48970.
DR   RefSeq; WP_033698561.1; NZ_PGDZ01000245.1.
DR   AlphaFoldDB; P56953; -.
DR   SMR; P56953; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1176
FT                   /note="Pesticidal crystal protein Cry1Cb"
FT                   /id="PRO_0000174037"
SQ   SEQUENCE   1176 AA;  132868 MW;  108233494C2AC018 CRC64;
     MENNIQNQCV PYNCLSNPEE ILLDGERIST GNSSIDISLS LVQLLVSNFV PGGGFLVGLL
     DFVWGIVGPS PWDAFLVQIE QLINERIAAY ARSAAISNLE GLGNNFNIYV EAFKEWEADP
     DNPVTRTRVV DRFRILDGLL ERDIPSFRIA GFEVPLLSVY AQAANLHLAI LRDSSIFGAR
     WGLTTINVNE NYNRLIRHID EYANHCADTY NRGLNNLPKS TYQDWITYNR LRRDLTLTVL
     DIAAFFPSYD NRRYPIQSVG QLTREIYTDP LITFNPQLQS VAQLPTFNVM ESNAIRTPHL
     FDVLNNLTIF TDWFSVGRNF YWGGHRVISN RIGGGNITSP IYGREANQEP PRSFTFNGPV
     FRTLSNPTFR PLQQPWPAPP FNLRGVEGVE FSTPLNSFTY RGRGTVDSLT ELPPEDNSVP
     PREGYSHRLC HATFVQRSGT PFLTTGPVFS WTHRSATDRN IIYPDVINQI PLVKAFNLTS
     GTSVVRGPGF TGGDIIRTNV NGSVLSMSLN FSNTTLQRYR VRVRYAASQT MVMSVTVGGS
     TTGNQGFPST MSANGALTSQ SFRFAEFPVG ISASGSQGAS ISISNNVGRQ MFHLDRIEFL
     PVTSTFEEEY DLERAQEAVN ALFTSTNQLG LKTDVTDYHI DQVSNLVECL SDEFCLDEKR
     ELSEKVKHAK RLSDERNLLQ DRNFRSINGQ LDRGWRGSTD ITIQGGDDVF KENYVTLPGT
     FDECYPTYLY QKIDESKLKS YTRYELRGYI EDSQDLEIYL IRYNAKHEIV NVPGTGSLWP
     LSIENSIGPC GEPNRCAPHL EWNPNLDCSC RDGEKCAHHS HHFSLDIDVG CTDLNEDLGV
     WVIFKIKTQD GHARLGNLEF LEEKPLLGEA LARVKRAEKK WRDKREKLEW ETNIVYKEAK
     ESVDALFVNS QYDRLQADTN IAMIHAADKR VHRIREAYLP ELSVIPGVNA GIFEELEGRI
     FTAYSLYDAR NVIKNGDFNN GLLCWNLKGH VDVEEQNNHR SVLVVPEWEA EVSQEVRVCP
     GRGYILRVTA YKEGYGEGCV TIHEIEDNTD ELKFSNCVEE EVYPNNTVTC NDYTATQEEY
     GGAYTSRNHG YGKSYESNSS VQADYASVYE EKADTDGRRD NHCESNRGYG DYTPLPAGYV
     TKELEYFPET DKVWVEIGET EGTFIVDSVE LLLMEE