ID   CR1DB_BACTU             Reviewed;        1160 AA.
AC   Q45747;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Pesticidal crystal protein Cry1Db;
DE   AltName: Full=131 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryID(b);
GN   Name=cry1Db; Synonyms=cryID(b);
OS   Bacillus thuringiensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1428;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BTS00349A;
RA   Lambert B.;
RL   Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; Z22511; CAA80234.1; -; Genomic_DNA.
DR   PIR; S32647; S32647.
DR   RefSeq; WP_033700085.1; NZ_WJDC01000071.1.
DR   AlphaFoldDB; Q45747; -.
DR   SMR; Q45747; -.
DR   PATRIC; fig|1428.310.peg.5192; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1160
FT                   /note="Pesticidal crystal protein Cry1Db"
FT                   /id="PRO_0000174039"
SQ   SEQUENCE   1160 AA;  130969 MW;  B18B18748B40695E CRC64;
     MDINHQNQCI PYNCLSNPDA ILLDAERLET GNTVADISLG LINFLYSNFV PGGGFIVGLL
     ELIWGFVGPS QWEIFLAQIE QLISQRIEEF ARNQAISRLE GLSNNYEIYT ETFRAWEKDP
     SNPALREEMR TQFNVMNSAL IAAIPLLRVR NYEVALLSVY VQAANLHLSV LRDVSVYGQR
     WGFDPATVNS RYSDLTRLIH VYTDHCVDTY NDGLKNLEGS RLSDWVVYNR FRRRLTISVL
     DIIAFFPNYD IEAYPIQTAS QLTREVYLDL PFVNETLSPP ASYPTFSAAE SAIIRSPHLV
     DFLNSFTIYT DSLASYAYWG GHLVNSFRTG TTTNLIRSPL YGREGNTERP VTISASPSVP
     IFRTLSYFTG LNNNNPVAGI EGVEFQNTIS RSIYRKSGPI DSFSELPPQD VSVSPAIGYS
     HRLCHATFLE RISGPRIAGT VFSWTHRSAS PINEVSPSRI TQIPWVKAHT LASGASVIKG
     PGFTGGDILT RNSMGDLGAL RVTFTGRLPQ SYYIRFRYAS VANRSGTFRY SQPPSYGISF
     PKTMDAGEAL TSRSFAHTTL FTPITFSRAQ EEFDLYIQSG VYIDRIEFIP VDATFESEIN
     LERAQKAVNA LFTSTNQLGL KTDVTDYHID QVSNLVECLS DEFCLDEKRE LSEKVKHAKR
     LSDERNLLQD PNFRGINRQP DRGWRGSTDI TIQGGDDVFK ENYVTLTGTF DECYPTYLYQ
     KIDESKLKAY TRYQLRGYIE DSQDLEIYLI RYNAKHEIVN VPGTGSLWPL SVQSPIGKCG
     EPNRCAPHLE WNPDLDCSCR DEEKCAHHSH HFSLDIDVGC TDLNEDLGVW VIFKIKTQDG
     HARLGNLEFL EEKPLVGEAL ARVKRAEKKW RDKREKLELE TNIVYKEAKE SVDALFVNSQ
     YDQLQADTNI AMIHAADKRV HSIREAYLPE LSVIPGVNAG IFEELEGRIF TAYSLYDARN
     VIKNGDFNNG LSCWNVKGHV DVEEQNNHRS VLVVPEWEAE VSQEVRVCPG RGYILRVTAY
     KEGYGEGCVT IHEVDNNTDE LKFSNCEKEQ VYPGNTVACN DYNKNHGANA CSSRNRGYDE
     SYESNSSIPA DYAPVYEEEA YTDGQRGNPC EFNRGHTPLP AGYVTAELEY FPETDTVWVE
     IGETEGTFIV DSVELLLMEE