ID   CR1FB_BACTM             Reviewed;        1169 AA.
AC   O66377; Q9RC19;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Pesticidal crystal protein Cry1Fb;
DE   AltName: Full=132 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIF(b);
GN   Name=cry1Fb; Synonyms=cryIF(b), cryINA67-1;
OS   Bacillus thuringiensis subsp. morrisoni.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1441;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Song F., Zhang J., Ding Z., Chen Z., Li G., Huang D.;
RT   "A novel cry1Fb gene from Bacillus thuringiensis subsp. morrisoni.";
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=INA67;
RA   Masuda K., Asano S.;
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; AF062350; AAF21767.1; -; Genomic_DNA.
DR   EMBL; AB012288; BAA25298.1; -; Genomic_DNA.
DR   AlphaFoldDB; O66377; -.
DR   SMR; O66377; -.
DR   ABCD; O66377; 1 sequenced antibody.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1169
FT                   /note="Pesticidal crystal protein Cry1Fb"
FT                   /id="PRO_0000174043"
FT   CONFLICT        338
FT                   /note="V -> I (in Ref. 2; BAA25298)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        382
FT                   /note="G -> A (in Ref. 2; BAA25298)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1002
FT                   /note="V -> I (in Ref. 2; BAA25298)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1012
FT                   /note="E -> K (in Ref. 2; BAA25298)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1053
FT                   /note="Missing (in Ref. 2; BAA25298)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1085
FT                   /note="G -> R (in Ref. 2; BAA25298)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1169 AA;  132286 MW;  EFCAAF6F6EE7BC1E CRC64;
     MKNNIQNQCV PYNCLSNPEV EILSEERSTG RLPLDISLSL TRFLLSEFVP GVGVAFGLFD
     LIWGFITPSE WSLFLLQIEQ LIEQRIETLE RNRAITTLRG LADSYEVYLE ALREWEENPN
     NAQLREDVRI RFANTDDALI TAINNFTLTS FEIPLLSVYV QAANLHLSLL RDAVSFGQGW
     GLDIATVNNH YNRLINLIHR YTEHCLDTYN QGLENLRGTN TRQWSRFNQF RRELTLTVLD
     IVALFPNYDA RAYPIQTSSQ LTREIYTSSV IEDSPVSANI PNGFNRAEFG VRPPHLMDFM
     NSLFVTAETV RSQTVWGGHL VSSRNTAGNP INFPIYGVFN PGGAIWIADE DPRPFYRTLS
     DPVFVRGGFG NPHYVLGLRG VGFQQTGTNH TRTFRNSGTI DSLDEIPPQD NSGAPWNDYS
     HVLNHVTFVR WPGEIAGSDS WRAPMFSWTH RSADRTNIIN PNIITQIPAV KAHNLHSGST
     VVRGPGFTGG DLLRRTNTGT FADIRVNITG PLSQRYRVRI RYASTTDLQF FTRINGTSVN
     QGNFQRTMNR GGNLESGNFR TAGFSTPFSF SNAQSTFTLG TQAFSNQEVY IDRIEFVPAE
     VTFEAESDLE RAQKAVNALF TSTSQLGLKT NVTGYHIDQV SNLVACLSDE FCLDEKRELS
     EKVKHAKRLS DKRNLLQDPN FRGINRQPDH GWRGSTDITI QGGDDVFKEN YVTLPGTFDE
     CYPTYLYQKI DESKLKAYTR YQLRGYIEDS QDLEIYLIRY NSKHEIVNVP GTGSLWPLSV
     ENQIGPCGEP NRCAPHLEWN PDLHCSCRDG EKCVHHSHHF SLDIDVGCTD LNEDLGVWLI
     FKIKTQDGHA RLGNLEFLEE EPLLGEALAR VKRAEKKWRD KREKLQLETN IVYKEAKESV
     DALFVNSQYD RLQADTNIAM IHAADKRVHR IREAYLPELS VIPGVNAAIF EELEGRIFTA
     YSLYDARNVI KNGNFNNGLL CWNVKGHVDV EEQNNHRSVL VVPEWEAEVS QEVRVCPGRG
     YILRVTAYKE GYGEGCVTIH EVDNNTDELK FSSNCEKEQV YPGNTVACND YNKNHGANAC
     SSRNGGYDES YESNSSIPAD YAPVYEEEAY TDGQRGNPCE FNRGHTPLPA GYVTAELEYF
     PETDTVWVEI GETEGTFIVD SVELLLMEE