ID   CR1GA_BACTU             Reviewed;        1166 AA.
AC   Q45746;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Pesticidal crystal protein Cry1Ga;
DE   AltName: Full=132 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIG(a);
GN   Name=cry1Ga; Synonyms=cryIG(a);
OS   Bacillus thuringiensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1428;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BTS00349A;
RA   Lambert B.;
RL   Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; Z22510; CAA80233.1; -; Genomic_DNA.
DR   PIR; S32645; S32645.
DR   RefSeq; WP_033698569.1; NZ_WJDC01000155.1.
DR   AlphaFoldDB; Q45746; -.
DR   SMR; Q45746; -.
DR   PRIDE; Q45746; -.
DR   PATRIC; fig|1428.310.peg.1216; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1166
FT                   /note="Pesticidal crystal protein Cry1Ga"
FT                   /id="PRO_0000174044"
SQ   SEQUENCE   1166 AA;  132004 MW;  3A98B2D2CA086DCC CRC64;
     MEISDQNQYI PYNCLNNPES EIFNARNSNF GLVSQVSSGL TRFLLEAAVP EAGFALGLFD
     IIWGALGVDQ WSLFLRQIEQ LIRQEITELE RNRATAILTG LSSSYNLYVE ALREWENDPN
     NPASQERVRT RFRLTDDAIV TGLPTLAIRN LEVVNLSVYT QAANLHLSLL RDAVYFGERW
     GLTQANIEDL YTRLTSNIQE YSDHCARWYN QGLNEIGGIS RRYLDFQRDL TISVLDIVAL
     FPNYDIRTYP IPTQSQLTRE IYTSPVVAGN INFGLSIANV LRAPHLMDFI DRIVIYTNSV
     RSTPYWAGHE VISRRTGQGQ GNEIRFPLYG VAANAEPPVT IRPTGFTDEQ RQWYRARSRV
     VSFRSSGQDF SLVDAVGFLT IFSAVSIYRN GFGFNTDTID EIPIEGTDPF TGYSHRLCHV
     GFLASSPFIS QYARAPIFSW THRSATLTNT IAPDVITQIP LVKAFNLHSG ATIVKGPGFT
     GGDILRRTNV GSFGDMRVNI TAPLSQRYRV RIRYASTTDL QFYTNINGTT INIGNFSSTM
     DSGDDLQYGR FRVAGFTTPF TFSDANSTFT IGAFGFSPNN EVYIDRIEFV PAEVTFEAEY
     DLEKAQKAVN ALFTSSNQIG LKTDVTDYHI DKVSNLVECL SDEFCLDEKR ELSEKVKHAK
     RLSDERNLLQ DPNFRGINRQ PDRGWRGSTD ITIQGGDDVF KENYVTLPGT FDGCYPTYLY
     QKIDESKLKV YTRYQLRGYI EDSQDLEIYL IRYNAKHETV NVPGTGSLWP LSAQSPIGKC
     GEPNRCAPHL EWNPDLDCSC RNGEKCAHHS HHFSLDIDVG CTDLNEDLGV WVIFKIKTQD
     GHARLGNLEF LEEKPLLGEA LARVKRAEKK WRDKREKLEL ETNIVYKEAK ESVDALFVNS
     QYDQLQADTN IAMIHAADKR VHSIREAYLP ELSVIPGVNA AIFEELEGRI FTAFSLYDAR
     NVIKNGDFNN GLSCWNVKGH VDVEEQNNHR SVLVVPEWEA EVSQEVRVCP GRGYILRVTA
     YKEGYGEGCV TIHEIENNTD ELKFSNCVEE EVYPNNTVTC NDYTANQEEY KGAYTSHNRG
     YDEAYGNNPS VPADYTPVYE EKAYTDGRRE NPCESNRGYG DYTPLPAGYV TKELEYFPET
     DKVWIEIGET EGTFIVESVE LLLMEE