ID   CR1GB_BACTZ             Reviewed;        1169 AA.
AC   Q9ZAZ6;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Pesticidal crystal protein Cry1Gb;
DE   AltName: Full=133 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIG(b);
GN   Name=cry1Gb; Synonyms=cryH2, cryIG(b);
OS   Bacillus thuringiensis subsp. wuhanensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=52024;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HD-525;
RX   PubMed=10688690; DOI=10.1007/s002849910046;
RA   Kuo W.-S., Lin J.-H., Tzeng C.-C., Kao S.-S., Chak K.-F.;
RT   "Cloning of two new cry genes from Bacillus thuringiensis subsp. wuhanensis
RT   strain.";
RL   Curr. Microbiol. 40:227-232(2000).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of lepidopteran larvae. Toxic to Pieris rapae.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; U70725; AAD10291.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9ZAZ6; -.
DR   SMR; Q9ZAZ6; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1169
FT                   /note="Pesticidal crystal protein Cry1Gb"
FT                   /id="PRO_0000174045"
SQ   SEQUENCE   1169 AA;  132906 MW;  D1EFC1508A8B10BD CRC64;
     MEINNQNQCV PYNCLNNPES EILNVAIFSS EQVAEIHLKI TRLILENFLP GGSFAFGLFD
     LIWGIFNEDQ WSAFLRQVEE LINQRITEFA RGQAIQRLVG FGRSYDEYIL ALKEWENDPD
     NPASKERVRT RFRTTDDALL TGVPLMAIPG FELATLSVYA QSANLHLALL RDAVFFGERW
     GLTQTNINDL YSRLKNSIRD YTNHCVRFYN IGLGNLNVIR PEYYRFQREL TISVLDLVAL
     FPNYDIRTYP IPTKSQLTRE IYTDPIISPG AQAGYTLQDV LREPHLMDFL NRLIIYTGEY
     RGIRHWAGHE VESSRTGMMT NIRFPLYGTA ATAEPTRFIT PSTFPGLNLF YRTLSAPIFR
     DEPGANIIIR YRTSLVEGVG FIQPNNGEQL YRVRGTLDSL DQLPLEGESS LTEYSHRLCH
     VRFAQSLRNA EPLDYARVPM FSWTHRSATP TNTIDPDVIT QIPLVKAFNL HSGATVVRGP
     GFTGGDILRR TNAGNFGDMR VNITAPLSQR YRVRIRYAST ANLQFHTSIN GRAINQANFP
     ATMNSGENLQ SGSFRVAGFT TPFTFSDALS TFTIGAFSFS SNNEVYIDGI EFVPAEVTFA
     TESDQDRAQK AVNALFTSSN QIGLKTDVTN YHIDQVSNLV ECLSDEFCLD EKRELSEKVK
     HAKRLCDERN LLQDPNFRGI NREPDRGWRG STDITIQRGD DVFKENYVTL PGTFDECYPT
     YLYQKIDESK LKAYTRYELR GYIEDSQDLE IYLIRYNAKH ETVNVPGTGS LWPLSAQSPI
     GKCGEPNRCA THLEWNPDLD CSCRDGEKCA HHSHHFSLDI DVGCTDLNED LGVWVIFKIK
     TQDGHARLGN LEFLEEKPLL GEALARVKRA EKKWRDKREK LELETNIVYK EAKKSVDALF
     VNSQYDRLQA DTNIAIIHAA DKRVHSIREA YLPELSVIPG VNAAIFEELE GRIFTAYSLY
     DARNVIKNGD FNNGLSCWNV KGHVDVEEQN NHRSVLVVPE WEAEVSQEVR VCPGRGYILR
     VTAYKEGYGE GCVTIHEIED NTDELKFSNC VEEEIYPNNT VTCNDYTATQ EEYEGTYTSR
     NRGYDGAYES NSSVPADYAS AYEEKAYTDG RRDNTCESNR GYGDYTPLPA GYVTKELEYF
     PETDKVWIEI GETEGTFIVD SVELLLMEE