ID   CR1HA_BACTU             Reviewed;        1172 AA.
AC   Q45748;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Pesticidal crystal protein Cry1Ha;
DE   AltName: Full=133 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIH(a);
GN   Name=cry1Ha; Synonyms=cryIH(a);
OS   Bacillus thuringiensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1428;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BTS02069AA;
RA   Lambert B.;
RL   Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; Z22513; CAA80236.1; -; Genomic_DNA.
DR   PIR; S32689; S32689.
DR   AlphaFoldDB; Q45748; -.
DR   SMR; Q45748; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1172
FT                   /note="Pesticidal crystal protein Cry1Ha"
FT                   /id="PRO_0000174046"
SQ   SEQUENCE   1172 AA;  132981 MW;  9BEC1B1071C71270 CRC64;
     MEIINNQNQY VPYNCLSNPE NEILDIESLS SRSREQVAEI SLGLTRFLLE SLLPGASFGF
     ALFDIIWGVI GPDQWNLFLA QIEQLIDQRI EAHVRNQAIS RLEGLGDSYE VYIESLREWE
     ASPNNEALQQ DVRNRFSNTD NALITAIPIL REQGFEIPLL SVYVQAANLH LSLLRDAVYF
     GQRWGLDTVT VNNHYNRLIN LINTYSDHCA QWFNRGLDNF GGVSARYLDF QREVTISVLD
     IVALFPNYDI RTYPISTQSQ LTREIYTSPV AEPGASLNAN LQNILREPHL MDFLTRLVIY
     TGVQSGIYHW AGHEISSRTT GNLSSNIQFP LYGTAASADR AFNMNIHHSE TIYRTLSAPI
     YSVSGGISPN RTRVVEGVRF LIARDNNLDS LPFLYRKEGT LDSFTELPPE DESTPPYIGY
     SHRLCHARFA RSPVILEPSN FARLPVFSWT HRSASPTNEV SPSRITQIPW VKAHTLASGA
     SVIKGPGFTG GDIMTRNNIN LGDLGTLRVT VTGRLPQSYY IRLRYASVAN SSGVFRHLPQ
     PSYGISFPRT MGTDEPLTSR SFALTTLFTP ITLTRAQEEF NLTIPRGVYI DRIEFVPVDA
     TFEAGYDLER AQKAVNALFT STNQRGLKTD ITDYHIDQVS NLVECLSDEF CLDEKRELSE
     KVKHAKRLSD GRNLLQDRNF ISINGLLDRG WRGSTDITIQ GSDDVFKENY VTLPGTFDEC
     YPTYLYQKID ESKLKAYTRY QLRGYIEDSQ DLEIYLIRYN AKHEIVNVPG TGSLWPLSVE
     NSIGPCGESN RCAPHLEWNP NLDCSCRDGE KCAHHSHHFS LDIDVGCTDL NEDLGVWVIF
     KIKTQDGHAR IGNLEFLEEK PLVGEALARV KRAEKKWRDK RKKLEFETNI VYKEAKESVD
     ALFVNSQYDK LKADTNIAMI HAADKRVHRI REAYLPELSV IPGVNADIFE ELEGRIFTAY
     SLYDARNVIK NGDFNNGLLC WNVKGHVDVE EQNNHRSVLV VPEWEAEVSQ EVRVCPGRGY
     ILRVTAYKEG YGEGCVTIHE IEDNTDELKF SNCVEEEVYP SNTVTCNDYT ANQEEYEGTY
     TSRNQGYDEA YESNSSVPAN YASVYEEKAY TDGRRENSCE FNRGYRDYTP LPAGYVTKEL
     EYFPGTAKVW IEIGETEGTF IVDSVELLLM EE