ID   CR1HB_BACTM             Reviewed;        1155 AA.
AC   Q45718;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Pesticidal crystal protein Cry1Hb;
DE   AltName: Full=131 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIH(b);
GN   Name=cry1Hb; Synonyms=cryIH(b);
OS   Bacillus thuringiensis subsp. morrisoni.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1441;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BF190;
RA   Koo B.T., Choi S.-K., Shin B.-S., Park S.-H.;
RL   Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; U35780; AAA79694.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q45718; -.
DR   SMR; Q45718; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1155
FT                   /note="Pesticidal crystal protein Cry1Hb"
FT                   /id="PRO_0000174047"
SQ   SEQUENCE   1155 AA;  131063 MW;  BFC14EA82698990A CRC64;
     MEVNHQNECV PYNCLKNPKI EMLDIEGISS RSREQVAEIS LGLTRFLLES LLPGASFGFG
     LFDIIWGVIG PDQWSLFLTQ IEQLIDQRIE AHVRNQAISR LEGLGDSYEV YIESLREWEA
     SPNNESLQQD VRNRFSNTDN ALITAIPILR EQGFEIPLLT VYVQAANLHL SLLRDAVYFG
     QRWGLDTATV NNHYNRLINL INTYSDHCAQ WFNRGLDNFG VVTARYLDFQ REVTISVLDI
     VALFPNYDIR TYPIQTLSQL TREIYTSPVA EPGASLNVDL RNILREPHLM DFLTRLVIYT
     GVQGGIYHWA GHEISSRTTG NLSSNIQFPL YGTSANADRP FNLAIHYSET IYRTLSAPIY
     SVSGGISPNR TRAVEGVRFL TARDNNLNSL PFLYRKEGSL DSFTELPPED ENEPPYIGYS
     HRLCHARFAR SSVVLEPSNF ARIPVFSWTH RSAGPTNEVS SSRITQIPWV KAHTLDSGAF
     VIKGPGFTGG DILTRPNLGT LGALRVTLTG QLPQTYNIRI RYASIANRGG TLIFSQPPSY
     GLTFPKTMDI DEPLTSRSFA RTTLFTPITF TQAQAELNLT IQQGVYIDRI EFIPVNATFE
     AEYDLERAQE AVNALFTSSN QLGLKTDLTD YHIDQVSNLV DCLSDEFCID EKRELSEKVK
     HAKRLSDERN LLQDSNFRGI NRQPDRGWRG STDITIQGGN DVFKENYVTL PGTFDECYPT
     YLYQKIDESK LKAYTRYQLR GYIEDSQDLE IYLIRYNAKH ETVNVPGTGS LWPLSVESPI
     GKCGEPNRCV PQLEWNSNLD CSCRDGEKCA HHSHHFSLDI DVGCTDLNED LGVWVIFKIK
     TQDGHARLGN LEFLEEKPLL GEALARVKRA EKKWRDKRET LQLETNIVYK EAKESVDALF
     ANSQYNRLQA DTNIAMIHAA DKRVHRIREA YLPELSVIPG VNAGIFEELE GRIFTAFSLY
     DARNVIKNSD FNNGLSCWNV KGHVDIEEQN NHRSVLVVPE WEAEVSQKVH VCPGRGYILR
     VTAYKEGYGE GCVTIHEIED HTDELKFRNC EEDEVYPNNT RTCNAYPADQ EGYEGACTSR
     NRGYDEVYGN TPSLPADYAP IYEENAYTDG RRGNPCESSR GYGDYTPLPA GYETKELEYF
     PETDTVWPRN RYSVD