ID   CR1IC_BACTU             Reviewed;         719 AA.
AC   O87404;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Pesticidal crystal protein Cry1Ic;
DE   AltName: Full=81 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryII(c);
GN   Name=cry1Ic; Synonyms=cryII(c);
OS   Bacillus thuringiensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1428;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C18 / Egypt;
RA   Osman Y.A., Madkour M.A., Bulla L.A. Jr.;
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; AF056933; AAC62933.1; -; Genomic_DNA.
DR   AlphaFoldDB; O87404; -.
DR   SMR; O87404; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..719
FT                   /note="Pesticidal crystal protein Cry1Ic"
FT                   /id="PRO_0000174050"
SQ   SEQUENCE   719 AA;  81210 MW;  8370B3F06B905DFF CRC64;
     MKLKNPDKHQ TLSSNAKVDK IATDSLKNET DIELKNMNNE DYLRMSEHES IDPFVSASTI
     QTGIGIAGKI LGTLGVPFPG QIASLYSFIL GELWPKGKSQ WEIFMEHVEA IINRKISTYA
     RNKALTDLKG LGDALAVYHE SLESWVGNRN NTRARSVVKN QYIALELMFV QKLPSFAVSG
     EEVPLLPIYA QAANLHLLLL RDASIFEKNG GLSASEISTF YNRQVERTRD YSYHCVKWNN
     TGLNNLRATN GQSWVRYNQF RKDIELMVLD LVRVFPSYDT LVYPIKTTSQ LTREVYTDAI
     GTVDPNQALR STTWYNNNAP SFSAIEAAVI RSPHLLDFLE KVTIYSLLSR WSNTQYMNMW
     GGHRLESRPI GGALNTSTQG STNTSINPVT LQFTSRDFYR TESWAGLNLF LTQPVNGVPR
     VDFHWKFPTL PIASDNFYYL GYAGVGTQLQ DSENELPPET TGQPNYESYS HRLSHIGLIS
     GSHVKALVYS WTHRSADRTN TIEPNSITQI PLVKAFNLSS GAAVVRGPGF TGGHILRRTK
     SGTFGHIRVN INPPFAQRYR VRMSYASTTD LQFHTSINGK AINQGNFSAT MNRGEDLDYK
     TFRTVGFTTP FSFSDVQSTF TIGAWNFSSG NEVYIGRIEF VPVEVTYEAE YDFEKAQEKV
     TALFTSTNPR GLKTDVKDYH IDQVSNLVES LSDELYLDEK RELFEIVKYA KQIHIERNM