ID   CR1JA_BACTU             Reviewed;        1167 AA.
AC   Q45738;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Pesticidal crystal protein Cry1Ja;
DE   AltName: Full=133 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIJ(a);
GN   Name=cry1Ja; Synonyms=cryET4, cryIJ(a);
OS   Bacillus thuringiensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1428;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRRL B-21110 / EG5847;
RA   Donovan W.P., Tan Y., Jany C.S., Gonzalez J.M. Jr.;
RT   "Bacillus thuringiensis cryet4 and cryet5 toxin genes and proteins toxic to
RT   lepidopteran insects.";
RL   Patent number US5322687, 21-JUN-1994.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of many lepidopteran larvae.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; L32019; AAA22341.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q45738; -.
DR   SMR; Q45738; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1167
FT                   /note="Pesticidal crystal protein Cry1Ja"
FT                   /id="PRO_0000174052"
SQ   SEQUENCE   1167 AA;  132761 MW;  3B7357D14E655FC7 CRC64;
     MEINNQKQCI PYNCLSNPEE VLLDGERILP DIDPLEVSLS LLQFLLNNFV PGGGFISGLV
     DKIWGALRPS EWDLFLAQIE RLIDQRIEAT VRAKAITELE GLGRNYQIYA EAFKEWESDP
     DNEAAKSRVI DRFRILDGLI EANIPSFRII GFEVPLLSVY VQAANLHLAL LRDSVIFGER
     WGLTTKNVND IYNRQIREIH EYSNHCVDTY NTELERLGFR SIAQWRIYNQ FRRELTLTVL
     DIVALFPNYD SRLYPIQTFS QLTREIVTSP VSEFYYGVIN SGNIIGTLTE QQIRRPHLMD
     FFNSMIMYTS DNRREHYWSG LEMTAYFTGF AGAQVSFPLV GTRGESAPPL TVRSVNDGIY
     RILSAPFYSA PFLGTIVLGS RGEKFDFALN NISPPPSTIY RHPGTVDSLV SIPPQDNSVP
     PHRGSSHRLS HVTMRASSPI FHWTHRSATT TNTINPNAII QIPLVKAFNL HSGATVVRGP
     GFTGGDILRR TNTGTFADMR VNITGPLSQR YRVRIRYAST TDLQFFTRIN GTSVNQGNFQ
     RTMNRGDNLE SGNFRTAGFS TPFSFSNAQS TFTLGTQAFS NQEVYIDRIE FVPAEVTFEA
     ESDLERAQKA VNALFTSTNQ LGLKTDVTDY QIDQVSNLVE CLSDEFCLDE KRELSEKVKH
     AKRLSDKRNL LQDPNFTSIN RQLDRGWRGS TDITIQGGND VFKENYVTLP GTFDECYPTY
     LYQKIDESKL KAYTRYELRG YIEDSQDLEV YLIRYNAKHE TVNVPGTGSL WPLSVESPIG
     RCGEPNRCVP HIEWNPDLDC SCRDGEKCAH HSHHFSLDID VGCTDLNEDL GVWVIFKIKT
     QDGHARLGNL EFLEEKPLLG EALARVKRAE KKWRDKREQL QFETNIVYKE AKESVDALFV
     DSHYNRLQAD TNITMIHAAD KRVHRIREAY LPELSVIPGV NADIFEELEG LIFTAFSLYD
     ARNIIKNGDF NNGLSCWNVK GHVDIQQNDH RSVLVVPEWE SEVSQEVRVC PGRGYILRVT
     AYKEGYGEGC VTIHEIEDNT DELKFSNCIE EEVYPTDTGN DYTAHQGTTG CADACNSRNV
     GYEDGYEINT TASVNYKPTY EEEMYTDVRR DNHCEYDRGY GNHTPLPAGY VTKELEYFPE
     TDTVWIEIGE TEGTFIVDSV ELLLMEE