CR1KA_BACTM
ID CR1KA_BACTM Reviewed; 1215 AA.
AC Q45715;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Pesticidal crystal protein Cry1Ka;
DE AltName: Full=137 kDa crystal protein;
DE AltName: Full=Crystaline entomocidal protoxin;
DE AltName: Full=Insecticidal delta-endotoxin CryIK(a);
GN Name=cry1Ka; Synonyms=cry1K, cryIK(a);
OS Bacillus thuringiensis subsp. morrisoni.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1441;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=F190;
RX PubMed=8586263; DOI=10.1111/j.1574-6968.1995.tb07931.x;
RA Koo B.T., Park S.-H., Choi S.-K., Shin B.S., Kim J.I., Yu J.H.;
RT "Cloning of a novel crystal protein gene cry1K from Bacillus thuringiensis
RT subsp. morrisoni.";
RL FEMS Microbiol. Lett. 134:159-164(1995).
CC -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC epithelial cells of insects. Selectively toxic to Artogeia rapae but
CC not active on Plutella xylostella.
CC -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC and is accumulated both as an inclusion and as part of the spore coat.
CC -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC terminus.
CC -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR EMBL; U28801; AAB00376.1; -; Genomic_DNA.
DR AlphaFoldDB; Q45715; -.
DR SMR; Q45715; -.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.20.190.10; -; 1.
DR Gene3D; 2.100.10.10; -; 1.
DR InterPro; IPR041587; Cry_V.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR038979; Pest_crys.
DR InterPro; IPR005638; Pest_crys_C.
DR InterPro; IPR005639; Pest_crys_N.
DR InterPro; IPR036716; Pest_crys_N_sf.
DR InterPro; IPR001178; Pest_cryst_cen_dom.
DR InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR PANTHER; PTHR37003; PTHR37003; 1.
DR Pfam; PF17997; Cry1Ac_D5; 1.
DR Pfam; PF03944; Endotoxin_C; 1.
DR Pfam; PF00555; Endotoxin_M; 1.
DR Pfam; PF03945; Endotoxin_N; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF51096; SSF51096; 1.
DR SUPFAM; SSF56849; SSF56849; 1.
PE 2: Evidence at transcript level;
KW Sporulation; Toxin; Virulence.
FT CHAIN 1..1215
FT /note="Pesticidal crystal protein Cry1Ka"
FT /id="PRO_0000174054"
SQ SEQUENCE 1215 AA; 137379 MW; 7CAF7A3311893D9B CRC64;
MNSNRKNENE IINALSIPAV SNHSAQMDLS PDARIEDSLC VAEGNNIDPF VSASTVQTGI
SIAGRILGVL GVPFAGQLAS FYSFLVGELW PSGRDPWEIF MEHVEQIVRQ QQITDSVRDT
AIARLEGLGR GYRSYQQALE TWLDNRNDAR SRSIIRERYI ALELDITTAI PLFSIRNEEV
PLLMVYAQAA NLHLLLLRDA SLFGSEWGMS SADVNQYYQE QIRYTEEYSN HCVQWYNTGL
NRLRGTTAET WVRYNQFRRD LTLGVLDLVA LFPSYDTRTY PIPTTAQLTR EVYTDPNGVV
AGPNNSWFRN GASFSAIENA IIRQPHLYDF LTNLTIYTRR SQVGTTIMNL WAGHRITFNR
IQGGSTSEMV YGAITNPVSV SDIPFVNRDV YRTVSLAGGL GSLSGIRYGL TRVDFDMIFR
NHPDIVTGLF YHPGHAGIAT QVKDSDTELP PETTEQPNYR AFSHLLSHIS MGPTTQDVPP
VYSWTHQSAD RTNTINSDRI TQIPLVKAHT LQSGTTVVKG PGFTGGDILR RTSGGPFAFS
NVNLDFNLSQ RYRARIRYAS TTNLRIYVTV AGERIFAGQF DKTMDAGAPL TFQSFSYATI
NTAFTFPERS SSLTIGADTF SSGNEVYVDR FELIQVTATF EAESDLERAR KAVNALFTST
NPRGLKTDVT DYHIDQVSNL VECLSDEFCL DKKRELLEEV KYAKRLSDER NLLQDPTFTS
ISGQTDRGWI GSTGISIQGG DDIFKENYVR LPGTVDECYP TYLYQKIDES QLKSYTRYQL
RGYIEDSQDL EIYLIRYNAK HETLSVPGTE SPWPSSGVYP SGRCGEPNRC APRIEWNPDL
DCSCRYGEKC VHHSHHFSLD IDVGCTDLNE DLGVWVIFKI KTQDGHAKLG NLEFIEEKPL
LGKALSRVKR AEKKWRDKYE KLQLETKRVY TEAKESVDAL FVDSQYDKLQ ANTNIGIIHG
ADKQVHRIRE PYLSELPVIP SINAAIFEEL EGHIFKAYSL YDARNVIKNG DFNNGLSCWN
VKGHVDVQQN HHRSVLVLSE WEAEVSQKVR VCPDRGYILR VTAYKEGYGE GCVTIHEFED
NTDVLKFRNF VEEEVYPNNT VTCNDYTTNQ SAEGSTDACN SYNRGYEDGY ENRYEPNPSA
PVNYTPTYEE GMYTDTQGYN HCVSDRGYRN HTPLPAGYVT LELEYFPETE QVWIEIGETE
GTFIVGSVEL LLMEE