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CR1KA_BACTM
ID   CR1KA_BACTM             Reviewed;        1215 AA.
AC   Q45715;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Pesticidal crystal protein Cry1Ka;
DE   AltName: Full=137 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIK(a);
GN   Name=cry1Ka; Synonyms=cry1K, cryIK(a);
OS   Bacillus thuringiensis subsp. morrisoni.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1441;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=F190;
RX   PubMed=8586263; DOI=10.1111/j.1574-6968.1995.tb07931.x;
RA   Koo B.T., Park S.-H., Choi S.-K., Shin B.S., Kim J.I., Yu J.H.;
RT   "Cloning of a novel crystal protein gene cry1K from Bacillus thuringiensis
RT   subsp. morrisoni.";
RL   FEMS Microbiol. Lett. 134:159-164(1995).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects. Selectively toxic to Artogeia rapae but
CC       not active on Plutella xylostella.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; U28801; AAB00376.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q45715; -.
DR   SMR; Q45715; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1215
FT                   /note="Pesticidal crystal protein Cry1Ka"
FT                   /id="PRO_0000174054"
SQ   SEQUENCE   1215 AA;  137379 MW;  7CAF7A3311893D9B CRC64;
     MNSNRKNENE IINALSIPAV SNHSAQMDLS PDARIEDSLC VAEGNNIDPF VSASTVQTGI
     SIAGRILGVL GVPFAGQLAS FYSFLVGELW PSGRDPWEIF MEHVEQIVRQ QQITDSVRDT
     AIARLEGLGR GYRSYQQALE TWLDNRNDAR SRSIIRERYI ALELDITTAI PLFSIRNEEV
     PLLMVYAQAA NLHLLLLRDA SLFGSEWGMS SADVNQYYQE QIRYTEEYSN HCVQWYNTGL
     NRLRGTTAET WVRYNQFRRD LTLGVLDLVA LFPSYDTRTY PIPTTAQLTR EVYTDPNGVV
     AGPNNSWFRN GASFSAIENA IIRQPHLYDF LTNLTIYTRR SQVGTTIMNL WAGHRITFNR
     IQGGSTSEMV YGAITNPVSV SDIPFVNRDV YRTVSLAGGL GSLSGIRYGL TRVDFDMIFR
     NHPDIVTGLF YHPGHAGIAT QVKDSDTELP PETTEQPNYR AFSHLLSHIS MGPTTQDVPP
     VYSWTHQSAD RTNTINSDRI TQIPLVKAHT LQSGTTVVKG PGFTGGDILR RTSGGPFAFS
     NVNLDFNLSQ RYRARIRYAS TTNLRIYVTV AGERIFAGQF DKTMDAGAPL TFQSFSYATI
     NTAFTFPERS SSLTIGADTF SSGNEVYVDR FELIQVTATF EAESDLERAR KAVNALFTST
     NPRGLKTDVT DYHIDQVSNL VECLSDEFCL DKKRELLEEV KYAKRLSDER NLLQDPTFTS
     ISGQTDRGWI GSTGISIQGG DDIFKENYVR LPGTVDECYP TYLYQKIDES QLKSYTRYQL
     RGYIEDSQDL EIYLIRYNAK HETLSVPGTE SPWPSSGVYP SGRCGEPNRC APRIEWNPDL
     DCSCRYGEKC VHHSHHFSLD IDVGCTDLNE DLGVWVIFKI KTQDGHAKLG NLEFIEEKPL
     LGKALSRVKR AEKKWRDKYE KLQLETKRVY TEAKESVDAL FVDSQYDKLQ ANTNIGIIHG
     ADKQVHRIRE PYLSELPVIP SINAAIFEEL EGHIFKAYSL YDARNVIKNG DFNNGLSCWN
     VKGHVDVQQN HHRSVLVLSE WEAEVSQKVR VCPDRGYILR VTAYKEGYGE GCVTIHEFED
     NTDVLKFRNF VEEEVYPNNT VTCNDYTTNQ SAEGSTDACN SYNRGYEDGY ENRYEPNPSA
     PVNYTPTYEE GMYTDTQGYN HCVSDRGYRN HTPLPAGYVT LELEYFPETE QVWIEIGETE
     GTFIVGSVEL LLMEE
 
 
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