CR1L_HUMAN
ID CR1L_HUMAN Reviewed; 569 AA.
AC Q2VPA4; Q32MC9; Q8NEU7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Complement component receptor 1-like protein;
DE AltName: Full=Complement C4b-binding protein CR-1-like protein;
DE Flags: Precursor;
GN Name=CR1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-526 (ISOFORM 1), AND VARIANTS ASP-402 AND VAL-455.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 57-569 (ISOFORM 3), TISSUE SPECIFICITY,
RP INTERACTION WITH IC4, AND SUBCELLULAR LOCATION.
RC TISSUE=Bone marrow;
RX PubMed=14687939; DOI=10.1016/j.molimm.2003.09.010;
RA Logar C.M., Chen W., Schmitt H., Yu C.Y., Birmingham D.J.;
RT "A human CR1-like transcript containing sequence for a binding protein for
RT iC4 is expressed in hematopoietic and fetal lymphoid tissue.";
RL Mol. Immunol. 40:831-840(2004).
CC -!- SUBUNIT: Interacts with iC4 (methylamine-treated C4) but not for iC3
CC (methylamine-treated C3). {ECO:0000269|PubMed:14687939}.
CC -!- INTERACTION:
CC Q2VPA4; Q8NEL9-2: DDHD1; NbExp=3; IntAct=EBI-12330477, EBI-11062258;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14687939}. Membrane
CC {ECO:0000269|PubMed:14687939}. Secreted {ECO:0000269|PubMed:14687939}.
CC Note=Predominantly found in association with the membrane fraction, but
CC also located in the cytoplasm and in the supernatant.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q2VPA4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2VPA4-2; Sequence=VSP_031151, VSP_031152, VSP_031153;
CC Name=3;
CC IsoId=Q2VPA4-3; Sequence=VSP_031152, VSP_031153;
CC -!- TISSUE SPECIFICITY: Expressed in fetal liver and to a lesser extent in
CC fetal spleen and thymus. Expression appears to be limited to
CC hematopoietic and fetal lymphoid tissue. {ECO:0000269|PubMed:14687939}.
CC -!- SIMILARITY: Belongs to the receptors of complement activation (RCA)
CC family. {ECO:0000305}.
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DR EMBL; AL137789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL365178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109190; AAI09191.1; -; mRNA.
DR EMBL; BC109191; AAI09192.1; -; mRNA.
DR EMBL; AY114160; AAM47024.1; -; mRNA.
DR CCDS; CCDS44310.1; -. [Q2VPA4-1]
DR RefSeq; NP_783641.1; NM_175710.1. [Q2VPA4-1]
DR AlphaFoldDB; Q2VPA4; -.
DR SMR; Q2VPA4; -.
DR BioGRID; 107770; 12.
DR IntAct; Q2VPA4; 1.
DR STRING; 9606.ENSP00000421736; -.
DR GlyGen; Q2VPA4; 1 site.
DR iPTMnet; Q2VPA4; -.
DR PhosphoSitePlus; Q2VPA4; -.
DR BioMuta; CR1L; -.
DR DMDM; 296439386; -.
DR EPD; Q2VPA4; -.
DR jPOST; Q2VPA4; -.
DR MassIVE; Q2VPA4; -.
DR PaxDb; Q2VPA4; -.
DR PeptideAtlas; Q2VPA4; -.
DR PRIDE; Q2VPA4; -.
DR Antibodypedia; 53872; 37 antibodies from 10 providers.
DR DNASU; 1379; -.
DR Ensembl; ENST00000508064.7; ENSP00000421736.2; ENSG00000197721.17. [Q2VPA4-1]
DR GeneID; 1379; -.
DR KEGG; hsa:1379; -.
DR MANE-Select; ENST00000508064.7; ENSP00000421736.2; NM_175710.2; NP_783641.1.
DR UCSC; uc001hga.5; human. [Q2VPA4-1]
DR CTD; 1379; -.
DR DisGeNET; 1379; -.
DR GeneCards; CR1L; -.
DR HGNC; HGNC:2335; CR1L.
DR HPA; ENSG00000197721; Tissue enriched (bone).
DR MIM; 605886; gene.
DR neXtProt; NX_Q2VPA4; -.
DR OpenTargets; ENSG00000197721; -.
DR PharmGKB; PA26856; -.
DR VEuPathDB; HostDB:ENSG00000197721; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000164130; -.
DR InParanoid; Q2VPA4; -.
DR OMA; SDQCNAP; -.
DR OrthoDB; 46968at2759; -.
DR PhylomeDB; Q2VPA4; -.
DR TreeFam; TF334137; -.
DR PathwayCommons; Q2VPA4; -.
DR SignaLink; Q2VPA4; -.
DR BioGRID-ORCS; 1379; 49 hits in 1062 CRISPR screens.
DR ChiTaRS; CR1L; human.
DR GenomeRNAi; 1379; -.
DR Pharos; Q2VPA4; Tdark.
DR PRO; PR:Q2VPA4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q2VPA4; protein.
DR Bgee; ENSG00000197721; Expressed in bone marrow and 103 other tissues.
DR ExpressionAtlas; Q2VPA4; baseline and differential.
DR Genevisible; Q2VPA4; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IDA:MGI.
DR GO; GO:0045959; P:negative regulation of complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0030449; P:regulation of complement activation; IDA:MGI.
DR GO; GO:1903659; P:regulation of complement-dependent cytotoxicity; IDA:MGI.
DR CDD; cd00033; CCP; 8.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00084; Sushi; 8.
DR SMART; SM00032; CCP; 8.
DR SUPFAM; SSF57535; SSF57535; 8.
DR PROSITE; PS50923; SUSHI; 8.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Disulfide bond; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Secreted; Signal; Sushi.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..569
FT /note="Complement component receptor 1-like protein"
FT /id="PRO_0000317776"
FT DOMAIN 33..93
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 94..155
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 156..226
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 228..287
FT /note="Sushi 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 287..347
FT /note="Sushi 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 348..410
FT /note="Sushi 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 411..472
FT /note="Sushi 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 473..543
FT /note="Sushi 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 35..78
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 65..91
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 96..137
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 123..153
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 158..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 187..224
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 230..272
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 258..285
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 289..332
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 318..345
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 350..392
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 378..408
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 413..454
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 440..470
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 504..541
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT VAR_SEQ 1..263
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031151"
FT VAR_SEQ 444
FT /note="H -> F (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14687939,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031152"
FT VAR_SEQ 445..569
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14687939,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031153"
FT VARIANT 116
FT /note="R -> G (in dbSNP:rs2296158)"
FT /id="VAR_038677"
FT VARIANT 139
FT /note="I -> V (in dbSNP:rs3085)"
FT /id="VAR_038678"
FT VARIANT 402
FT /note="N -> D (in dbSNP:rs12729569)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_038679"
FT VARIANT 455
FT /note="I -> V (in dbSNP:rs6683902)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_038680"
FT VARIANT 491
FT /note="L -> P (in dbSNP:rs2796257)"
FT /id="VAR_038681"
SQ SEQUENCE 569 AA; 62714 MW; D49F7517E1347A5D CRC64;
MAPPVRLERP FPSRRFPGLL LAALVLLLSS FSDQCNVPEW LPFARPTNLT DDFEFPIGTY
LNYECRPGYS GRPFSIICLK NSVWTSAKDK CKRKSCRNPP DPVNGMAHVI KDIQFRSQIK
YSCPKGYRLI GSSSATCIIS GNTVIWDNKT PVCDRIICGL PPTIANGDFT SISREYFHYG
SVVTYHCNLG SRGKKVFELV GEPSIYCTSK DDQVGIWSGP APQCIIPNKC TPPNVENGIL
VSDNRSLFSL NEVVEFRCQP GFGMKGPSHV KCQALNKWEP ELPSCSRVCQ PPPDVLHAER
TQRDKDNFSP GQEVFYSCEP GYDLRGSTYL HCTPQGDWSP AAPRCEVKSC DDFLGQLPNG
HVLFPLNLQL GAKVDFVCDE GFQLKGSSAS YCVLAGMESL WNSSVPVCER KSCETPPVPV
NGMVHVITDI HVGSRINYSC TTGHRLIGHS SAECILSGNT AHWSMKPPIC QQIFCPNPPA
ILNGRHTGTP LGDIPYGKEV SYTCDPHPDR GMTFNLIGES TIRRTSEPHG NGVWSSPAPR
CELPVGAGSH DALIVGKFYE VFAEEFCHL
