ID   CR23_RANCA              Reviewed;          25 AA.
AC   P69032; P56235; P82117;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Caerin-2.3;
OS   Ranoidea caerulea (Green tree frog) (Litoria caerulea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Ranoidea.
OX   NCBI_TaxID=30344;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RC   TISSUE=Parotoid gland;
RA   Stone D.J.M., Waugh R.J., Bowie J.H., Wallace J.C., Tyler M.J.;
RT   "Peptides from Australian frogs. The structures of the caerins from Litoria
RT   caerula.";
RL   J. Chem. Res. 138:910-936(1993).
CC   -!- FUNCTION: Acts as a male sex pheromone that attracts females. Has no
CC       antimicrobial activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin parotoid and/or rostral
CC       glands.
CC   -!- MASS SPECTROMETRY: Mass=2364; Method=FAB; Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Caerin subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P69032; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005186; F:pheromone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR032021; Frog_Litoria.
DR   Pfam; PF16049; Antimicrobial24; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing; Pheromone; Secreted.
FT   PEPTIDE         1..25
FT                   /note="Caerin-2.3"
FT                   /id="PRO_0000043743"
SQ   SEQUENCE   25 AA;  2366 MW;  DDD82C36B49186B8 CRC64;
     GLVSSIGKAL GGLLADVVKS KGQPA