ID   CR2AA_BACTX             Reviewed;         633 AA.
AC   P0A378; O52764; P21253;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Pesticidal crystal protein Cry2Aa;
DE   AltName: Full=71 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIIA(a);
DE   AltName: Full=Mosquito factor;
DE   AltName: Full=P2 crystal protein;
GN   Name=cry2Aa; Synonyms=cryB1, cryII, cryIIA(a);
OS   Bacillus thuringiensis subsp. kenyae.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=33930;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=4A4C / HD-549;
RA   Misra H.S., Khairnar N.P., Mathur M., Donnelly R.J., Mahajan S.K.;
RL   Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of both dipteran (Aedes aegypti) and lepidopteran
CC       (Manduca sexta) larvae. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; AF047038; AAC04867.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0A378; -.
DR   SMR; P0A378; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR015214; Pest_cryst_cen_dom_Cry2A/18.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF09131; Endotoxin_mid; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   3: Inferred from homology;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..633
FT                   /note="Pesticidal crystal protein Cry2Aa"
FT                   /id="PRO_0000174056"
SQ   SEQUENCE   633 AA;  70748 MW;  E9C85CA1C9713587 CRC64;
     MNSVLNSGRT TICDAYNVVA HDPFSFEHKS LDTIQKEWME WKRTDHSLYV APVVGTVSSF
     LLKKVGSLIG KRILSELWGI IFPSGSTNLM QDILRETEQF LNQRLNTDTL ARVNAELIGL
     QANIREFNQQ VDNFLNPTQN PVPLSITSSV NTMQQLFLNR LPQFQIQGYQ LLLLPLFAQA
     ANMHLSFIRD VILNADEWGI SAATLRTYRD YLRNYTRDYS NYCINTYQTA FRGLNTRLHD
     MLEFRTYMFL NVFEYVSIWS LFKYQSLMVS SGANLYASGS GPQQTQSFTA QNWPFLYSLF
     QVNSNYILSG ISGTRLSITF PNIGGLPGST TTHSLNSARV NYSGGVSSGL IGATNLNHNF
     NCSTVLPPLS TPFVRSWLDS GTDREGVATS TNWQTESFQT TLSLRCGASS ARGNSNYFPD
     YFIRNISGVP LVIRNEDLTR PLHYNQIRNI ESPSGTPGGA RAYLVSVHNR KNNIYAANEN
     GTMIHLAPED YTGFTISPIH ATQVNNQTRT FISEKFGNQG DSLRFEQSNT TARYTLRGNG
     SSYNLYLRVS SIGNSTIRVT INGRVYTVSN VNTTTNNDGV NDNGARFPDI NIGNIVASDN
     TNVTLDINVT LNSGTPFDLM NIMFVPTNLP PLY