ID   CR35_RANGR              Reviewed;          22 AA.
AC   P0C2A9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Caerin-3.5;
OS   Ranoidea gracilenta (Dainty green tree frog) (Litoria gracilenta).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Ranoidea.
OX   NCBI_TaxID=95133;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AMIDATION AT LYS-22, MASS SPECTROMETRY, AND
RP   SYNTHESIS.
RC   TISSUE=Skin secretion;
RX   PubMed=16554081; DOI=10.1016/j.toxicon.2006.01.019;
RA   Maclean M.J., Brinkworth C.S., Bilusich D., Bowie J.H., Doyle J.R.,
RA   Llewellyn L.E., Tyler M.J.;
RT   "New caerin antibiotic peptides from the skin secretion of the dainty green
RT   tree frog Litoria gracilenta. Identification using positive and negative
RT   ion electrospray mass spectrometry.";
RL   Toxicon 47:664-675(2006).
CC   -!- FUNCTION: Shows significant activity against Gram-positive organisms,
CC       but is less effective against Gram-negative organisms.
CC       {ECO:0000269|PubMed:16554081}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC   -!- MASS SPECTROMETRY: Mass=2410; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:16554081};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Caerin subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C2A9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..22
FT                   /note="Caerin-3.5"
FT                   /id="PRO_0000271474"
FT   MOD_RES         22
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000269|PubMed:16554081"
SQ   SEQUENCE   22 AA;  2413 MW;  0B28DB2200D4367C CRC64;
     GLWEKVKEKA NELVSGIVEG VK