ID   CR3AA_BACTM             Reviewed;         644 AA.
AC   P0A380; P07130; P21255;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Pesticidal crystal protein Cry3Aa;
DE   AltName: Full=73 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIIIA(a);
DE   Flags: Precursor;
GN   Name=cry3Aa; Synonyms=bt13, cry3A, cryC, cryIIIa, cryIIIA(a);
OS   Bacillus thuringiensis subsp. morrisoni.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1441;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=EG2158;
RX   PubMed=3146015; DOI=10.1007/bf00330468;
RA   Donovan W.P., Gonzalez J.M. Jr., Gilbert M.P., Dankocsik C.C.;
RT   "Isolation and characterization of EG2158, a new strain of Bacillus
RT   thuringiensis toxic to coleopteran larvae, and nucleotide sequence of the
RT   toxin gene.";
RL   Mol. Gen. Genet. 214:365-372(1988).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of Coleoptera.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; M37207; AAA50255.1; -; Genomic_DNA.
DR   RefSeq; WP_052574943.1; NZ_CP010582.1.
DR   AlphaFoldDB; P0A380; -.
DR   SMR; P0A380; -.
DR   TCDB; 1.C.2.1.7; the channel-forming Delta-endotoxin insecticidal crystal protein (icp) family.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   PROPEP          1..57
FT                   /note="Removed in mature form"
FT                   /id="PRO_0000006343"
FT   CHAIN           58..644
FT                   /note="Pesticidal crystal protein Cry3Aa"
FT                   /id="PRO_0000006344"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   644 AA;  73109 MW;  EFCFF1CEEFDA9683 CRC64;
     MNPNNRSEHD TIKTTENNEV PTNHVQYPLA ETPNPTLEDL NYKEFLRMTA DNNTEALDSS
     TTKDVIQKGI SVVGDLLGVV GFPFGGALVS FYTNFLNTIW PSEDPWKAFM EQVEALMDQK
     IADYAKNKAL AELQGLQNNV EDYVSALSSW QKNPVSSRNP HSQGRIRELF SQAESHFRNS
     MPSFAISGYE VLFLTTYAQA ANTHLFLLKD AQIYGEEWGY EKEDIAEFYK RQLKLTQEYT
     DHCVKWYNVG LDKLRGSSYE SWVNFNRYRR EMTLTVLDLI ALFPLYDVRL YPKEVKTELT
     RDVLTDPIVG VNNLRGYGTT FSNIENYIRK PHLFDYLHRI QFHTRFQPGY YGNDSFNYWS
     GNYVSTRPSI GSNDIITSPF YGNKSSEPVQ NLEFNGEKVY RAVANTNLAV WPSAVYSGVT
     KVEFSQYNDQ TDEASTQTYD SKRNVGAVSW DSIDQLPPET TDEPLEKGYS HQLNYVMCFL
     MQGSRGTIPV LTWTHKSVDF FNMIDSKKIT QLPLVKAYKL QSGASVVAGP RFTGGDIIQC
     TENGSAATIY VTPDVSYSQK YRARIHYAST SQITFTLSLD GAPFNQYYFD KTINKGDTLT
     YNSFNLASFS TPFELSGNNL QIGVTGLSAG DKVYIDKIEF IPVN