ID   CR3BA_BACTO             Reviewed;         659 AA.
AC   P17969;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Pesticidal crystal protein Cry3Ba;
DE   AltName: Full=75 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIIIB(a);
GN   Name=cry3Ba; Synonyms=cryIIIb, cryIIIB(a);
OS   Bacillus thuringiensis subsp. tolworthi.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=43F;
RX   PubMed=2320431; DOI=10.1093/nar/18.5.1305;
RA   Sick A., Gaertner F.H., Wong A.;
RT   "Nucleotide sequence of a coleopteran-active toxin gene from a new isolate
RT   of Bacillus thuringiensis subsp. tolworthi.";
RL   Nucleic Acids Res. 18:1305-1305(1990).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of Coleoptera.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; X17123; CAA34983.1; -; Genomic_DNA.
DR   PIR; S10228; S10228.
DR   AlphaFoldDB; P17969; -.
DR   SMR; P17969; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..659
FT                   /note="Pesticidal crystal protein Cry3Ba"
FT                   /id="PRO_0000174060"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   659 AA;  75159 MW;  5A5B214FF84168CA CRC64;
     MIRMGGRKMN PNNRSEYDTI KVTPNSELPT NHNQYPLADN PNSTLEELNY KEFLRMTADN
     STEVLDSSTV KDAVGTGISV VGQILGVVGV PFAGALTSFY QSFLNAIWPS DADPWKAFMA
     QVEVLIDKKI EEYAKSKALA ELQGLQNNFE DYVNALDSWK KAPVNLRSRR SQDRIRELFS
     QAESHFRNSM PSFAVSKFEV LFLPTYAQAA NTHLLLLKDA QVFGEEWGYS SEDIAEFYQR
     QLKLTQQYTD HCVNWYNVGL NSLRGSTYDA WVKFNRFRRE MTLTVLDLIV LFPFYDVRLY
     SKGVKTELTR DIFTDPIFTL NALQEYGPTF SSIENSIRKP HLFDYLRGIE FHTRLRPGYS
     GKDSFNYWSG NYVETRPSIG SNDTITSPFY GDKSIEPIQK LSFDGQKVYR TIANTDIAAF
     PDGKIYFGVT KVDFSQYDDQ KNETSTQTYD SKRYNGYLGA QDSIDQLPPE TTDEPLEKAY
     SHQLNYAECF LMQDRRGTIP FFTWTHRSVD FFNTIDAEKI TQLPVVKAYA LSSGASIIEG
     PGFTGGNLLF LKESSNSIAK FKVTLNSAAL LQRYRVRIRY ASTTNLRLFV QNSNNDFLVI
     YINKTMNIDG DLTYQTFDFA TSNSNMGFSG DTNDFIIGAE SFVSNEKIYI DKIEFIPVQ