ID   CR3CA_BACTK             Reviewed;         649 AA.
AC   Q45744;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Pesticidal crystal protein Cry3Ca;
DE   AltName: Full=73 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIIIC(a);
GN   Name=cry3Ca; Synonyms=cryIIIC(a), cryIIId;
OS   Bacillus thuringiensis subsp. kurstaki.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=29339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BTI109P;
RX   PubMed=1544571; DOI=10.1016/0378-1119(92)90457-z;
RA   Lambert B., Theunis W., Aguda R., Van Audenhove K., Decock C., Jansens S.,
RA   Seurinck J., Peferoen M.;
RT   "Nucleotide sequence of gene cryIIID encoding a novel coleopteran-active
RT   crystal protein from strain BTI109P of Bacillus thuringiensis subsp.
RT   kurstaki.";
RL   Gene 110:131-132(1992).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of Coleoptera.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; X59797; CAA42469.1; -; Genomic_DNA.
DR   PIR; JH0261; JH0261.
DR   AlphaFoldDB; Q45744; -.
DR   SMR; Q45744; -.
DR   PRIDE; Q45744; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..649
FT                   /note="Pesticidal crystal protein Cry3Ca"
FT                   /id="PRO_0000174062"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   649 AA;  73027 MW;  8FF1F0B47957AC49 CRC64;
     MNPNNRSEHD TIKATENNEV SNNHAQYPLA DTPTLEELNY KEFLRRTTDN NVEALDSSTT
     KDAIQKGISI IGDLLGVVGF PYGGALVSFY TNLLNTIWPG EDPLKAFMQQ VEALIDQKIA
     DYAKDKATAE LQGLKNVFKD YVSALDSWDK TPLTLRDGRS QGRIRELFSQ AESHFRRSMP
     SFAVSGYEVL FLPTYAQAAN THLLLLKDAQ IYGTDWGYST DDLNEFHTKQ KDLTIEYTNH
     CAKWYKAGLD KLRGSTYEEW VKFNRYRREM TLTVLDLITL FPLYDVRTYT KGVKTELTRD
     VLTDPIVAVN NMNGYGTTFS NIENYIRKPH LFDYLHAIQF HSRLQPGYFG TDSFNYWSGN
     YVSTRSSIGS DEIIRSPFYG NKSTLDVQNL EFNGEKVFRA VANGNLAVWP VGTGGTKIHS
     GVTKVQFSQY NDRKDEVRTQ TYDSKRNVGG IVFDSIDQLP PITTDESLEK AYSHQLNYVR
     CFLLQGGRGI IPVFTWTHKS VDFYNTLDSE KITQIPFVKA FILVNSTSVV AGPGFTGGDI
     IKCTNGSGLT LYVTPAPDLT YSKTYKIRIR YASTSQVRFG IDLGSYTHSI SYFDKTMDKG
     NTLTYNSFNL SSVSRPIEIS GGNKIGVSVG GIGSGDEVYI DKIEFIPMD