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CR3L2_XENLA
ID   CR3L2_XENLA             Reviewed;         525 AA.
AC   A2VD01;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Cyclic AMP-responsive element-binding protein 3-like protein 2;
DE            Short=cAMP-responsive element-binding protein 3-like protein 2;
DE   Contains:
DE     RecName: Full=Processed cyclic AMP-responsive element-binding protein 3-like protein 2;
GN   Name=creb3l2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in unfolded protein response
CC       (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted
CC       into ER membranes, with N-terminal DNA-binding and transcription
CC       activation domains oriented toward the cytosolic face of the membrane.
CC       In response to ER stress, transported to the Golgi, where it is cleaved
CC       in a site-specific manner by resident proteases S1P/mbtps1 and
CC       S2P/mbtps2. The released N-terminal cytosolic domain is translocated to
CC       the nucleus to effect transcription of specific target genes. Plays a
CC       critical role in chondrogenesis. May protect neuroblastoma cells from
CC       ER stress-induced death. In vitro activates transcription of target
CC       genes via direct binding to the CRE site.
CC       {ECO:0000250|UniProtKB:Q8BH52}.
CC   -!- SUBUNIT: Binds DNA as a dimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8BH52}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q8BH52}. Note=ER membrane resident protein. Upon
CC       ER stress, translocated to the Golgi apparatus where it is cleaved. The
CC       cytosolic N-terminal fragment (processed cyclic AMP-responsive element-
CC       binding protein 3-like protein 1) is transported into the nucleus.
CC       {ECO:0000250|UniProtKB:Q8BH52}.
CC   -!- SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding
CC       protein 3-like protein 2]: Nucleus {ECO:0000250|UniProtKB:Q8BH52}.
CC       Note=Upon ER stress, translocated into the nucleus.
CC       {ECO:0000250|UniProtKB:Q8BH52}.
CC   -!- PTM: Upon ER stress, translocated to the Golgi apparatus, where it is
CC       processed by regulated intramembrane proteolysis (RIP) to release the
CC       cytosol-facing N-terminal transcription factor domain. The cleavage is
CC       performed sequentially by site-1 and site-2 proteases (S1P/mbtps1 and
CC       S2P/mbtps2). {ECO:0000250|UniProtKB:Q8BH52}.
CC   -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily. {ECO:0000305}.
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DR   EMBL; BC129061; AAI29062.1; -; mRNA.
DR   RefSeq; NP_001091333.1; NM_001097864.1.
DR   AlphaFoldDB; A2VD01; -.
DR   SMR; A2VD01; -.
DR   DNASU; 100037168; -.
DR   GeneID; 100037168; -.
DR   KEGG; xla:100037168; -.
DR   CTD; 100037168; -.
DR   Xenbase; XB-GENE-996214; creb3l2.L.
DR   OrthoDB; 644485at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 100037168; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0035497; F:cAMP response element binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0051216; P:cartilage development; ISS:UniProtKB.
DR   GO; GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
DR   InterPro; IPR029804; BBF2H7.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   PANTHER; PTHR46004:SF2; PTHR46004:SF2; 1.
DR   Pfam; PF00170; bZIP_1; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Endoplasmic reticulum;
KW   Glycoprotein; Membrane; Nucleus; Reference proteome; Signal-anchor;
KW   Transcription; Transcription regulation; Transmembrane;
KW   Transmembrane helix; Unfolded protein response.
FT   CHAIN           1..525
FT                   /note="Cyclic AMP-responsive element-binding protein 3-like
FT                   protein 2"
FT                   /id="PRO_0000288072"
FT   CHAIN           1..?
FT                   /note="Processed cyclic AMP-responsive element-binding
FT                   protein 3-like protein 2"
FT                   /id="PRO_0000296214"
FT   TOPO_DOM        1..382
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        404..525
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          299..362
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          85..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..330
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          309..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..362
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   MOTIF           433..436
FT                   /note="S1P recognition"
FT                   /evidence="ECO:0000250|UniProtKB:Q70SY1"
FT   COMPBIAS        86..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..260
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..338
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        490
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        509
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        522
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   525 AA;  57625 MW;  44644A533FA13D9F CRC64;
     MEIMESGDPV IQWDRKLSEL SEAAESDSLY NNTPFSELLD DSALLDVLGQ LMGDPFLTEK
     YEMMEVEMNP SSPSPMIKAE HSYSLCGDSR PQSPFTHASS DDNFSDTDLT GDDWCLNGEL
     TATTPTTKIK VEIPLEETPG LTPSVTLATS AVSASPEVGV SSQLPVPEQV KLLSPVALPQ
     IKLEPHEVDQ FLNLCPKEVA PTEALQMPPT PPSSHGSDSE GGQSPTRSLP PSSPVQSQAG
     GKMAARSPSA LSNSPLLTAP HKLQGSGPLM LTEEEKRTLV AEGYPIPTKL PLTKAEEKAL
     KKIRRKIKNK ISAQESRRKK KEYMDSLEKR VENSSSENSE LRKKVEVLES TNRTLLQQLQ
     RLQAMVTGKV TRSCKAAGTQ TGTCLMMVVL CFAVIFGSFT QNLDMYSSSS KTIHEPSQYS
     APESYAASIV RSRKLLIFEE HQAVEELHSS AVMLETQDTW EVQADTISKQ QAALLEELHL
     SQEKPFSLSN DSSSDMPVRH RFTSEFGHND TTKVIELDRT VNTTS
 
 
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