ID   CR4AA_BACTK             Reviewed;         281 AA.
AC   P84613;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Insecticidal crystal toxin protein;
OS   Bacillus thuringiensis subsp. kurstaki.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=29339;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Spore;
RA   Gomase V.S., Chikhale N.J., Vankhede G.N.;
RL   Submitted (JUL-2005) to UniProtKB.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects. Active against Mamestra brassicae.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during
CC       sporulation.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family.
CC       {ECO:0000250|UniProtKB:P16480}.
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DR   AlphaFoldDB; P84613; -.
DR   SMR; P84613; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Sporulation; Toxin; Virulence.
FT   CHAIN           1..281
FT                   /note="Insecticidal crystal toxin protein"
FT                   /id="PRO_0000174064"
FT   REGION          54..78
FT                   /note="Antigenic epitope"
FT   REGION          91..104
FT                   /note="Antigenic epitope"
FT   REGION          108..116
FT                   /note="Antigenic epitope"
FT   REGION          131..148
FT                   /note="Antigenic epitope"
FT   REGION          160..172
FT                   /note="Antigenic epitope"
FT   REGION          189..196
FT                   /note="Antigenic epitope"
FT   REGION          208..216
FT                   /note="Antigenic epitope"
FT   REGION          221..236
FT                   /note="Antigenic epitope"
FT   REGION          247..256
FT                   /note="Antigenic epitope"
SQ   SEQUENCE   281 AA;  31811 MW;  0C61277395BD60E4 CRC64;
     MDFFITNGTR LLEKELTAGS GQITYDVNKN IFGLPILKRR ENQGNPTLFP TYDNYSHILS
     FIKSLSIPAT YKTQVYTFAW THSSVDPKNT IYTHLTTQIP AVKANSLGTA SKVVQGPGHT
     GGDLIDFKDH FKITCQHSNF QQSYFIRIRY ASNGSANTRA VINLSIPGVA ELGMALNPTF
     SGTDYTNLKY KDFQYLEFSN EVKFAPNQNI SLVFNRSDVY TNTTVLIDKI EFLPITRSIR
     EDREKQKLET VQQIINTFYA NPIKNTLQSE LTDYDIDQAA N