CR7AB_BACUA
ID CR7AB_BACUA Reviewed; 1138 AA.
AC Q45707;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Pesticidal crystal protein Cry7Ab;
DE AltName: Full=130 kDa crystal protein;
DE AltName: Full=Crystaline entomocidal protoxin;
DE AltName: Full=Insecticidal delta-endotoxin CryVIIA(b);
GN Name=cry7Ab; Synonyms=cryVIIA(b);
OS Bacillus thuringiensis subsp. dakota.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=132268;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HD511;
RA Payne J.M., Fu J.M.;
RT "Coleopteran-active Bacillus thuringiensis isolates and genes encoding
RT coleopteran-active toxins.";
RL Patent number US5286486, 15-FEB-1994.
CC -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC epithelial cells of Coleoptera.
CC -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC and is accumulated both as an inclusion and as part of the spore coat.
CC -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC terminus.
CC -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR EMBL; U04367; AAA21120.1; -; Genomic_DNA.
DR AlphaFoldDB; Q45707; -.
DR SMR; Q45707; -.
DR PRIDE; Q45707; -.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.20.190.10; -; 1.
DR Gene3D; 2.100.10.10; -; 1.
DR InterPro; IPR041587; Cry_V.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR038979; Pest_crys.
DR InterPro; IPR005638; Pest_crys_C.
DR InterPro; IPR005639; Pest_crys_N.
DR InterPro; IPR036716; Pest_crys_N_sf.
DR InterPro; IPR001178; Pest_cryst_cen_dom.
DR InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR PANTHER; PTHR37003; PTHR37003; 1.
DR Pfam; PF17997; Cry1Ac_D5; 1.
DR Pfam; PF03944; Endotoxin_C; 1.
DR Pfam; PF00555; Endotoxin_M; 1.
DR Pfam; PF03945; Endotoxin_N; 1.
DR SUPFAM; SSF49785; SSF49785; 2.
DR SUPFAM; SSF51096; SSF51096; 1.
DR SUPFAM; SSF56849; SSF56849; 1.
PE 2: Evidence at transcript level;
KW Sporulation; Toxin; Virulence.
FT CHAIN 1..1138
FT /note="Pesticidal crystal protein Cry7Ab"
FT /id="PRO_0000174073"
SQ SEQUENCE 1138 AA; 129779 MW; 01DF7072C074CE88 CRC64;
MNLNNLGGYE DSNRTLNNSL NYPTQKALSP SLKNMNYQDF LSITEREQPE ALASGNTAIN
TVVSVTGATL SALGVPGASF ITNFYLKITG LLWPHNKNIW DEFMTEVETL IEQKIEQYAR
NKALAELEGL GNNLTIYQQA LEDWLNNPDD PATITRVIDR FRILDALFES YMPSFRVAGY
EIPLLTVYAQ AANLHLALLR DSTLYGDKWG FTQNNIEENY NRQKKHISEY SNHCVKWYNS
GLSRLNGSTY EQWINYNRFR REMILMVLDI AAVFPIYDPR MYSMETSTQL TREVYTDPIS
LSISNPDIGP SFSQMENTAF RTPHLVDYLD ELYIYTSKYK AFSHEIQPDL FYWCVHKVSF
KKSEQSNLYT TGIYGKTSGY ISSGAYSFRG NDIYRTLAAP SVVVYPYTQN YGVEQVEFYG
VKGHVHYRGD NKYDLTYDSI DQLPPDGEPI HEKYTHRLCH ATAISKSTPD YDNATIPIFS
WTHRSAEYYN RIYPNKIKKI PAVKMYKLDD LSTVVKGPGF TGGDLVKRGS NGYIGDIKAT
VNSPLSQKYR VRVRYATSVS GLFNVFINDE IALQKNFQST VETIGEGKDL TYGSFGYIEY
STTIQFPNEH PKITLHLNHL SNNSPFYVDS IEFIPVDVNY DEKEKLEKAQ KAVNTLFTEG
RNALQKYVTD YKVDQVSILV DCISGDLYPN EKRELQNLVK YAKRLSYSRN LLLDPTFDSI
NSSEENGWYG SNGIVIGNGD FVFKGNYLIF SGTNDTQYPT YLYQKIDESK LKEYSRYKLK
GFIESSQDLE AYVIRYDAKH RTLDVSDNLL PDILPENTCG EPNRCAAQQY LDENPSSECS
SMQDGILSDS HSFSLNIDTG SINHNENLGI WVLFKISTLE GYAKFGNLEV IEDGPVIGEA
LARVKRQETK WRNKLAQMTT ETQAIYTRAK QALDNLFANA QDSHLKIDVT FAEIAAARKI
VQSIREVYMS WLSVVPGVNH PIFTELSGRV QRAFQLYDVR NVVRNGRFLN GLSDWIVTSD
VNVQEENGNN VLVLNNWDAQ VLRNVKLYQD RGYVLRVTAR KIGIGEGYIT ITDEEGHTDQ
LRFTACEEID ASNAFISGYI TKELEFFPDT EKVHIEIGET EGIFLVESIE LFLMEELC
