CR7AB_BACUK
ID CR7AB_BACUK Reviewed; 1138 AA.
AC Q45708;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Pesticidal crystal protein Cry7Ab;
DE AltName: Full=130 kDa crystal protein;
DE AltName: Full=Crystaline entomocidal protoxin;
DE AltName: Full=Insecticidal delta-endotoxin CryVIIA(b);
GN Name=cry7Ab; Synonyms=cryVIIA(b);
OS Bacillus thuringiensis serovar kumamotoensis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=132267;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HD867;
RA Payne J.M., Fu J.M.;
RT "Coleopteran-active Bacillus thuringiensis isolates and genes encoding
RT coleopteran-active toxins.";
RL Patent number US5286486, 15-FEB-1994.
CC -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC epithelial cells of Coleoptera.
CC -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC and is accumulated both as an inclusion and as part of the spore coat.
CC -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC terminus.
CC -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR EMBL; U04368; AAA21121.1; -; Genomic_DNA.
DR AlphaFoldDB; Q45708; -.
DR SMR; Q45708; -.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.20.190.10; -; 1.
DR Gene3D; 2.100.10.10; -; 1.
DR InterPro; IPR041587; Cry_V.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR038979; Pest_crys.
DR InterPro; IPR005638; Pest_crys_C.
DR InterPro; IPR005639; Pest_crys_N.
DR InterPro; IPR036716; Pest_crys_N_sf.
DR InterPro; IPR001178; Pest_cryst_cen_dom.
DR InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR PANTHER; PTHR37003; PTHR37003; 1.
DR Pfam; PF17997; Cry1Ac_D5; 1.
DR Pfam; PF03944; Endotoxin_C; 1.
DR Pfam; PF00555; Endotoxin_M; 1.
DR Pfam; PF03945; Endotoxin_N; 1.
DR SUPFAM; SSF49785; SSF49785; 2.
DR SUPFAM; SSF51096; SSF51096; 1.
DR SUPFAM; SSF56849; SSF56849; 1.
PE 2: Evidence at transcript level;
KW Sporulation; Toxin; Virulence.
FT CHAIN 1..1138
FT /note="Pesticidal crystal protein Cry7Ab"
FT /id="PRO_0000174074"
SQ SEQUENCE 1138 AA; 129659 MW; E12DC80C0A56D1DA CRC64;
MNLNNLGGYE DSNRTLNNSL NYPTQKALSP SLKNMNYQDF LSITEREQPE ALASGNTAIN
TVVSVTGATL SALGVPGASF ITNFYLKITG LLWPHDKNIW DEFMTEVETL IEQKIEQYAR
NKALAELEGL GNNLTIYQQA LEDWLNNPDD PATITRVIDR FRILDALFES YMPSFRVAGY
EIPLLTVYAQ AANLHLALLR DSTLYGDKWE FTQNNIEENY NRQKKHISEY SNHCVKWYNS
GLSRLNGSTY EQWINYNRFR REMILMVLDI AAVFPIYDPR MYSMETSTQL TREVYTDPIS
LSISNPGIGP SFSQMENTAI RTPHLVDYLD ELYIYTSKYK AFSHEIQPDL FYWSAHKVSF
KQSEQSNLYT TGIYGKTSGY ISSGAYSFRG NDIYRTLAAP SVVVYPYTQN YGVEQVEFYG
VKGHVHYRGD NKYDLTYDSI DQLPPDGEPI HEKYTHRLCH ATAISKSTPD YDNATIPIFS
WTHRSAEYYN RIYPNKITKI PAVKMYKLGD TSTVVKGPGF TGGDLVKRGS NGYIGDIKAT
VNSPLSQNYR VRVRYATNVS GQFNVYINDK ITLQRKFQNT VETIGEGKDL TYGSFGYIEY
STTIQFPDKH PKITLHLSDL SNNSSFYVDS IEFIPVDVNY DEKEKLEKAQ KAVNTLFTEG
RNALQKDVTD YKVDQVSILV DCISGDLYPN EKRELQNLVK YAKRLSYSRN LLLDPTFDSI
NSSEENGWYG SNGIVIGNGD FVFKGNYLIF SGTNDTQYPT YLYQKIDESK LKEYTRYKLK
GFIESSQDLE AYVIRYDAKH RTLDVSDNLL PDILPENTCG EPNRCAAQQY LDENPSSECS
SMQDGILSDS HSFSLNIDIG SINHNENLGI WVLFKISTLE GYAKFGNLEV IEDGPVIGEA
LARVKRQETK WRNKLAQLTT ETQAIYTRAK QALDNLFANA QDSHLKIDVT FAEIAAARKI
VQSIREAYMS WLSVVPGVNH PIFTELSERV QRAFQLYDVR NVVRNGRFLN GLSDWIVTSD
VKVQEENGNN VLVLNNWDAQ VLQNVKLYQD RGYILRVTAR KIGIGEGYIT ITDEEGHTVQ
LRFTACEVID ASNAFISGYI TKELEFFPDT EKVHIEIGET EGIFLVESIE LFLMEELC