ID   CR9CA_BACTO             Reviewed;        1157 AA.
AC   Q45733;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Pesticidal crystal protein Cry9Ca;
DE   AltName: Full=130 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIXC(a);
GN   Name=cry9Ca; Synonyms=cryIXC(a);
OS   Bacillus thuringiensis subsp. tolworthi.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=BTS02618A;
RX   PubMed=8572715; DOI=10.1128/aem.62.1.80-86.1996;
RA   Lambert B., Buysse L., Decock C., Jansens S., Piens C., Saey B.,
RA   Seurinck J., van Audenhove K., van Rie J., van Vliet A., Peferoen M.;
RT   "A Bacillus thuringiensis insecticidal crystal protein with a high activity
RT   against members of the family Noctuidae.";
RL   Appl. Environ. Microbiol. 62:80-86(1996).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of Lepidoptera larvae. Has a fairly broad spectrum of
CC       activity against members of the Pyralidae, Plutellidae, Sphingidae and
CC       Noctuidae families. It was the first insecticidal crystal protein
CC       characterized with activity against cutworms. No activity is observed
CC       against some beetles, such as the Colorado potato beetle.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; Z37527; CAA85764.1; -; Genomic_DNA.
DR   PIR; A59350; S49247.
DR   AlphaFoldDB; Q45733; -.
DR   SMR; Q45733; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Sporulation; Toxin; Virulence.
FT   CHAIN           1..1157
FT                   /note="Pesticidal crystal protein Cry9Ca"
FT                   /id="PRO_0000174078"
SQ   SEQUENCE   1157 AA;  129776 MW;  C364391EF7FDFB8A CRC64;
     MNRNNQNEYE IIDAPHCGCP SDDDVRYPLA SDPNAALQNM NYKDYLQMTD EDYTDSYINP
     SLSISGRDAV QTALTVVGRI LGALGVPFSG QIVSFYQFLL NTLWPVNDTA IWEAFMRQVE
     ELVNQQITEF ARNQALARLQ GLGDSFNVYQ RSLQNWLADR NDTRNLSVVR AQFIALDLDF
     VNAIPLFAVN GQQVPLLSVY AQAVNLHLLL LKDASLFGEG WGFTQGEIST YYDRQLELTA
     KYTNYCETWY NTGLDRLRGT NTESWLRYHQ FRREMTLVVL DVVALFPYYD VRLYPTGSNP
     QLTREVYTDP IVFNPPANVG LCRRWGTNPY NTFSELENAF IRPPHLFDRL NSLTISSNRF
     PVSSNFMDYW SGHTLRRSYL NDSAVQEDSY GLITTTRATI NPGVDGTNRI ESTAVDFRSA
     LIGIYGVNRA SFVPGGLFNG TTSPANGGCR DLYDTNDELP PDESTGSSTH RLSHVTFFSF
     QTNQAGSIAN AGSVPTYVWT RRDVDLNNTI TPNRITQLPL VKASAPVSGT TVLKGPGFTG
     GGILRRTTNG TFGTLRVTVN SPLTQQYRLR VRFASTGNFS IRVLRGGVSI GDVRLGSTMN
     RGQELTYESF FTREFTTTGP FNPPFTFTQA QEILTVNAEG VSTGGEYYID RIEIVPVNPA
     REAEEDLEAA KKAVASLFTR TRDGLQVNVT DYQVDQAANL VSCLSDEQYG HDKKMLLEAV
     RAAKRLSRER NLLQDPDFNT INSTEENGWK ASNGVTISEG GPFFKGRALQ LASARENYPT
     YIYQKVDASV LKPYTRYRLD GFVKSSQDLE IDLIHHHKVH LVKNVPDNLV SDTYSDGSCS
     GINRCDEQHQ VDMQLDAEHH PMDCCEAAQT HEFSSYINTG DLNASVDQGI WVVLKVRTTD
     GYATLGNLEL VEVGPLSGES LEREQRDNAK WNAELGRKRA EIDRVYLAAK QAINHLFVDY
     QDQQLNPEIG LAEINEASNL VESISGVYSD TLLQIPGINY EIYTELSDRL QQASYLYTSR
     NAVQNGDFNS GLDSWNTTMD ASVQQDGNMH FLVLSHWDAQ VSQQLRVNPN CKYVLRVTAR
     KVGGGDGYVT IRDGAHHQET LTFNACDYDV NGTYVNDNSY ITEEVVFYPE TKHMWVEVSE
     SEGSFYIDSI EFIETQE