ID   CR9EA_BACTA             Reviewed;        1150 AA.
AC   Q9ZNL9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Pesticidal crystal protein Cry9Ea;
DE   AltName: Full=130 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIXE(a);
GN   Name=cry9Ea; Synonyms=cryIXE(a);
OS   Bacillus thuringiensis subsp. aizawai.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1433;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SSK-10;
RA   Midoh N., Oyama K.;
RT   "Bacillus thuringiensis cry gene for insecticidal crystal protein.";
RL   Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; AB011496; BAA34908.1; -; Genomic_DNA.
DR   RefSeq; WP_021727542.1; NZ_NFEV01000132.1.
DR   AlphaFoldDB; Q9ZNL9; -.
DR   SMR; Q9ZNL9; -.
DR   PRIDE; Q9ZNL9; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1150
FT                   /note="Pesticidal crystal protein Cry9Ea"
FT                   /id="PRO_0000174080"
SQ   SEQUENCE   1150 AA;  129896 MW;  7D6AB93D6EDC97EB CRC64;
     MNRNNPNEYE IIDAPYCGCP SDDDVRYPLA SDPNAAFQNM NYKEYLQTYD GDYTGSLINP
     NLSINPRDVL QTGINIVGRI LGFLGVPFAG QLVTFYTFLL NQLWPTNDNA VWEAFMAQIE
     ELIDQKISAQ VVRNALDDLT GLHDYYEEYL AALEEWLERP NGARANLVTQ RFENLHTAFV
     TRMPSFGTGP GSQRDAVALL TVYAQAANLH LLLLKDAEIY GARWGLQQGQ INLYFNAQQE
     RTRIYTNHCV ETYNRGLEDV RGTNTESWLN YHRFRREMTL MAMDLVALFP FYNVRQYPNG
     ANPQLTREIY TDPIVYNPPA NQGICRRWGN NPYNTFSELE NAFIRPPHLF ERLNRLTISR
     NRYTAPTTNS FLDYWSGHTL QSQHANNPTT YETSYGQITS NTRLFNTTNG ARAIDSRARN
     FGNLYANLYG VSSLNIFPTG VMSEITNAAN TCRQDLTTTE ELPLENNNFN LLSHVTFLRF
     NTTQGGPLAT LGFVPTYVWT REDVDFTNTI TADRITQLPW VKASEIGGGT TVVKGPGFTG
     GDILRRTDGG AVGTIRANVN APLTQQYRIR LRYASTTSFV VNLFVNNSAA GFTLPSTMAQ
     NGSLTYESFN TLEVTHTIRF SQSDTTLRLN IFPSISGQEV YVDKLEIVPI NPTREAEEDL
     EDAKKAVASL FTRTRDGLQV NVTDYQVDQA ANLVSCLSDE QYGHDKKMLL EAVRAAKRLS
     RERNLLQDPD FNEINSTEEN GWKASNGVTI SEGGPFFKGR ALQLASAREN YPTYIYQKVD
     ASTLKPYTRY KLDGFVQSSQ DLEIDLIHHH KVHLVKNVPD NLVSDTYSDG SCSGINRCEE
     QHQVDVQLDA EDHPKDCCEA AQTHEFSSYI HTGDLNASVD QGIWVVLQVR TTDGYATLGN
     LELVEVGPLS GESLEREQRD NAKWNEEVGR KRAETDRIYQ DAKQAINHLF VDYQDQQLSP
     EVGMADIIDA QNLIASISDV YSDAVLQIPG INYEMYTELS NRLQQASYLY TSRNVVQNGD
     FNSGLDSWNA TTDTAVQQDG NMHFLVLSHW DAQVSQQFRV QPNCKYVLRV TAKKVGNGDG
     YVTIQDGAHH RETLTFNACD YDVNGTHVND NSYITKELVF YPKTEHMWVE VSETEGTFYI
     DSIEFIETQE