CRAC1_MOUSE
ID CRAC1_MOUSE Reviewed; 646 AA.
AC Q8R555; Q3UF32; Q3UF40; Q8BMF1; Q8R3V8;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Cartilage acidic protein 1;
DE AltName: Full=68 kDa chondrocyte-expressed protein;
DE Short=CEP-68;
DE AltName: Full=ASPIC;
DE AltName: Full=Protein CRTAC1-B;
DE Flags: Precursor;
GN Name=Crtac1; Synonyms=Aspic1, Cep68;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RA Steck E., Richter W.;
RT "A novel form of CRTAC1 expressed in human and mouse brain generated by
RT alternative splicing of a newly identified last exon.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Olfactory bulb, Spinal cord, and Sympathetic ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-646.
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH24472.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ421516; CAD13395.1; -; mRNA.
DR EMBL; AK149020; BAE28721.1; -; mRNA.
DR EMBL; AK032328; BAC27817.1; -; mRNA.
DR EMBL; AK049801; BAC33924.1; -; mRNA.
DR EMBL; AK149069; BAE28729.1; -; mRNA.
DR EMBL; BC024472; AAH24472.1; ALT_INIT; mRNA.
DR CCDS; CCDS29828.1; -.
DR RefSeq; NP_660105.3; NM_145123.4.
DR AlphaFoldDB; Q8R555; -.
DR STRING; 10090.ENSMUSP00000044858; -.
DR iPTMnet; Q8R555; -.
DR PhosphoSitePlus; Q8R555; -.
DR CPTAC; non-CPTAC-5599; -.
DR MaxQB; Q8R555; -.
DR PaxDb; Q8R555; -.
DR PeptideAtlas; Q8R555; -.
DR PRIDE; Q8R555; -.
DR ProteomicsDB; 285301; -.
DR Antibodypedia; 2172; 164 antibodies from 27 providers.
DR DNASU; 72832; -.
DR Ensembl; ENSMUST00000048630; ENSMUSP00000044858; ENSMUSG00000042401.
DR GeneID; 72832; -.
DR KEGG; mmu:72832; -.
DR UCSC; uc008hno.1; mouse.
DR CTD; 55118; -.
DR MGI; MGI:1920082; Crtac1.
DR VEuPathDB; HostDB:ENSMUSG00000042401; -.
DR eggNOG; ENOG502QQ5V; Eukaryota.
DR GeneTree; ENSGT00390000013726; -.
DR HOGENOM; CLU_027473_0_0_1; -.
DR InParanoid; Q8R555; -.
DR OMA; FFVANYG; -.
DR OrthoDB; 986490at2759; -.
DR PhylomeDB; Q8R555; -.
DR TreeFam; TF333171; -.
DR BioGRID-ORCS; 72832; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Cep68; mouse.
DR PRO; PR:Q8R555; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8R555; protein.
DR Bgee; ENSMUSG00000042401; Expressed in molar tooth and 142 other tissues.
DR ExpressionAtlas; Q8R555; baseline and differential.
DR Genevisible; Q8R555; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030426; C:growth cone; IDA:MGI.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007413; P:axonal fasciculation; IMP:MGI.
DR GO; GO:1900121; P:negative regulation of receptor binding; IDA:MGI.
DR GO; GO:0021772; P:olfactory bulb development; IMP:MGI.
DR Gene3D; 2.130.10.130; -; 1.
DR InterPro; IPR027039; Crtac1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR011519; UnbV_ASPIC.
DR PANTHER; PTHR16026:SF4; PTHR16026:SF4; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF13517; FG-GAP_3; 2.
DR Pfam; PF07593; UnbV_ASPIC; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF69318; SSF69318; 1.
DR PROSITE; PS01187; EGF_CA; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; EGF-like domain; Extracellular matrix; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..646
FT /note="Cartilage acidic protein 1"
FT /id="PRO_0000007498"
FT REPEAT 47..89
FT /note="FG-GAP 1; atypical"
FT REPEAT 106..148
FT /note="FG-GAP 2; atypical"
FT REPEAT 284..334
FT /note="FG-GAP 3; atypical"
FT REPEAT 396..438
FT /note="FG-GAP 4; atypical"
FT DOMAIN 560..606
FT /note="EGF-like"
FT DISULFID 564..578
FT /evidence="ECO:0000255"
FT DISULFID 571..587
FT /evidence="ECO:0000255"
FT DISULFID 593..606
FT /evidence="ECO:0000255"
FT CONFLICT 191
FT /note="R -> G (in Ref. 2; BAC27817)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="R -> Q (in Ref. 2; BAC27817)"
FT /evidence="ECO:0000305"
FT CONFLICT 471
FT /note="S -> C (in Ref. 2; BAE28721)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 646 AA; 70325 MW; 154C45E636DF2D98 CRC64;
MAPSADPGMV RMALLLLPPL WLLPLTGGSQ RAEPMFTAVT NSVLPPDYDS NPTQLNYGVA
VTDVDHDGDF EIVVAGYTGP NLVLKYNRAQ NRLVNIAVDE RSSPYYALRD RQGNAIGVTA
CDIDGDGREE IYFLNTNNAF SGVATYTDKL FKFRNNRWED ILSDDVNVAR GVASLFAGRS
VACVDRTGSG RYSIYIANYA YGDVGPDALI EMDPEASDLS RGILALRDVA AEAGVSKYTA
GRGVSVGPIL SSSASDIFCD NENGPNFLFH NQGNGTFVDT AASAGVDDPH QHGRGVALAD
FNRDGKVDIV YGNWNGPHRL YLQMSAHGKV RFRDIASPKF STPSPVRTVI AADFDNDQEL
EVFFNNIAYR SSSANRLFRV IRREHGDPLI EELNPGDALE PEGRGTGGVV TDFDGDGMLD
LILSHGESMA QPLSVFRGNQ GFSNNWLRVV PRTRFGAFAR GAKVVLYTKK SGAHLRIIDG
GSGYLCEMEP VAHFGLGRDE ASSVEVTWPD GKMVSRSVAS EEMNSVLEIL YPQDEDKLQN
TAPLECGQGF SQQDNGHCMD TNECIQFPFV CPRDKPVCVN TYGSYRCRTN KRCNRGYEPN
EDGTACVAQV AFLGGYSSAA FRLSEPLSQA SYLSLGLGLC LQLYAL
