ID   CRAC1_XENTR             Reviewed;         647 AA.
AC   Q0V9M0; A1XF96;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Cartilage acidic protein 1;
DE   AltName: Full=ASPIC;
DE   Flags: Precursor;
GN   Name=crtac1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Redruello B., Canario A.V.M., Power D.M.;
RT   "Identification of extracellular matrix proteins from lower vertebrates.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI21478.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; DQ351712; ABC86210.1; -; mRNA.
DR   EMBL; BC121477; AAI21478.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001072373.1; NM_001078905.1.
DR   AlphaFoldDB; Q0V9M0; -.
DR   STRING; 8364.ENSXETP00000063347; -.
DR   PaxDb; Q0V9M0; -.
DR   DNASU; 779826; -.
DR   GeneID; 779826; -.
DR   KEGG; xtr:779826; -.
DR   CTD; 55118; -.
DR   Xenbase; XB-GENE-5881785; crtac1.
DR   eggNOG; ENOG502QQ5V; Eukaryota.
DR   InParanoid; Q0V9M0; -.
DR   OrthoDB; 986490at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007413; P:axonal fasciculation; IBA:GO_Central.
DR   Gene3D; 2.130.10.130; -; 1.
DR   InterPro; IPR027039; Crtac1.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR011519; UnbV_ASPIC.
DR   PANTHER; PTHR16026:SF4; PTHR16026:SF4; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF13517; FG-GAP_3; 2.
DR   Pfam; PF07593; UnbV_ASPIC; 1.
DR   SMART; SM00179; EGF_CA; 1.
DR   SUPFAM; SSF69318; SSF69318; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; EGF-like domain; Extracellular matrix; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..647
FT                   /note="Cartilage acidic protein 1"
FT                   /id="PRO_0000383351"
FT   REPEAT          48..90
FT                   /note="FG-GAP 1; atypical"
FT   REPEAT          107..149
FT                   /note="FG-GAP 2; atypical"
FT   REPEAT          285..335
FT                   /note="FG-GAP 3; atypical"
FT   REPEAT          397..439
FT                   /note="FG-GAP 4; atypical"
FT   DOMAIN          561..607
FT                   /note="EGF-like"
FT   DISULFID        565..579
FT                   /evidence="ECO:0000255"
FT   DISULFID        572..588
FT                   /evidence="ECO:0000255"
FT   DISULFID        594..607
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   647 AA;  70824 MW;  E5E5D7BD49212166 CRC64;
     MMLPADFFVP VSKMMLLALL LSIIICCGGA QRSEPMFTAV TDTVLPQDYD SNPTQLNYGV
     AITDVDNDGD FEVVVAGYNG PNLVLKYIKE KGHLVNIAVD ERSSPYYALR DRQGNAIGVA
     ACDIDGDGRE EIYFLNTNNA FSGIATYSDK LFTFRNGRWE DLFSDEVNLR RGVANRFSGR
     SVACIDRKGS GRYSFYIANY ANGNVGPHAL IELDETASNL SRGIIVLSNV AAELGLNKYT
     GGRGIAVGPI VNSAASDIFC DNENGPNFLF QNKGDGTFVD IASSTGVDDV YQHGRGVALA
     DFNRDGKVDI VYGNWNGPHR LFLQMNTNGK VRFRDIATQK FSMPSPIRTV IAADFDNDQE
     LEVFFNNIAY RGPSANRMFR VGRREHADPF MEELNPGDAS EPDGRGTGGA VTDFDGDGML
     DLILSHGESM AQPLSVFKGK QGLKNNWLRV IPRTKFGAFA RGAKVVLYTK KSGAHLRIID
     GGSGYLCEME PVAHFGLGKD EASSLEVTWP DGKIFTRSVA EGEINSVLDI AYPHEDDTVT
     KPTDIECGQG FSVNENGRCT DTDECIQFPF VCPREKPVCI NTYGGYKCRP NRRCSRGFEP
     NEDGTACVAQ VAYFGSYPSS ASRSQALFLH CTASLLGLGF YFQIYTL