ID   CRADD_PONAB             Reviewed;         199 AA.
AC   Q5R6I4;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Death domain-containing protein CRADD;
DE   AltName: Full=Caspase and RIP adapter with death domain;
GN   Name=CRADD;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein that associates with PIDD1 and the caspase
CC       CASP2 to form the PIDDosome, a complex that activates CASP2 and
CC       triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex
CC       through its interaction with RIPK1 and TRADD and may play a role in the
CC       tumor necrosis factor-mediated signaling pathway.
CC       {ECO:0000250|UniProtKB:P78560}.
CC   -!- SUBUNIT: Forms a complex named the PIDDosome with PIDD1 and CASP2.
CC       Interacts (via Death domain) with RIPK1 (via Death domain); the
CC       interaction is direct. Interacts with TRADD. Interacts with TNFRSF1A.
CC       {ECO:0000250|UniProtKB:P78560}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O88843}. Nucleus
CC       {ECO:0000250|UniProtKB:O88843}.
CC   -!- DOMAIN: The Death domain mediates the interaction with PIDD1 and the
CC       formation of a complex composed of 5 PIDD1 and 7 CRADD proteins which
CC       in turn probably recruit 7 CASP2 to form the PIDDosome. The Death
CC       domain mediates a direct interaction with the Death domain of RIPK1.
CC       {ECO:0000250|UniProtKB:P78560}.
CC   -!- DOMAIN: The CARD domain mediates a direct interaction with CASP2.
CC       {ECO:0000250|UniProtKB:P78560}.
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DR   EMBL; CR860505; CAH92626.1; -; mRNA.
DR   RefSeq; NP_001126538.1; NM_001133066.1.
DR   RefSeq; XP_009246375.1; XM_009248100.1.
DR   RefSeq; XP_009246376.1; XM_009248101.1.
DR   AlphaFoldDB; Q5R6I4; -.
DR   SMR; Q5R6I4; -.
DR   STRING; 9601.ENSPPYP00000005515; -.
DR   Ensembl; ENSPPYT00000005728; ENSPPYP00000005515; ENSPPYG00000004835.
DR   GeneID; 100173528; -.
DR   KEGG; pon:100173528; -.
DR   CTD; 8738; -.
DR   eggNOG; ENOG502R26C; Eukaryota.
DR   GeneTree; ENSGT00390000014448; -.
DR   HOGENOM; CLU_118159_0_0_1; -.
DR   InParanoid; Q5R6I4; -.
DR   OMA; NHPHNLQ; -.
DR   OrthoDB; 1346117at2759; -.
DR   TreeFam; TF333055; -.
DR   Proteomes; UP000001595; Chromosome 12.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:1905369; C:endopeptidase complex; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0070513; F:death domain binding; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
DR   GO; GO:0097190; P:apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IEA:Ensembl.
DR   GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Ensembl.
DR   CDD; cd08327; CARD_RAIDD; 1.
DR   CDD; cd08319; Death_RAIDD; 1.
DR   Gene3D; 1.10.533.10; -; 2.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR042148; CARD_RAIDD.
DR   InterPro; IPR037939; CRADD.
DR   InterPro; IPR037926; CRADD_Death.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   PANTHER; PTHR15034; PTHR15034; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF00531; Death; 1.
DR   SMART; SM00114; CARD; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; SSF47986; 2.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..199
FT                   /note="Death domain-containing protein CRADD"
FT                   /id="PRO_0000079328"
FT   DOMAIN          1..91
FT                   /note="CARD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00046"
FT   DOMAIN          116..188
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
SQ   SEQUENCE   199 AA;  22725 MW;  47B923B3B6F68F59 CRC64;
     MEARDKQVLR LLRLELGAEV LVEGLVLQYL YQEGILTENH VQEINAQTTG LRKTMLLLDI
     LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG DRLTGIPSHI LNSSPSDRQI
     NQLAQRLGPE WEPVVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFIRWRQR FGKQATFQSL
     HNGLRAVEVD PSLLLHMLE