ID   CRA_PLAFA               Reviewed;         162 AA.
AC   P04923;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Circumsporozoite protein-related antigen;
DE            Short=CRA;
DE   Flags: Precursor;
OS   Plasmodium falciparum.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2410913; DOI=10.1073/pnas.82.15.5121;
RA   Coppel R.L., Favaloro J.M., Crewther P.E., Burkot T.R., Bianco A.E.,
RA   Stahl H.-D., Kemp D.J., Anders R.F., Brown G.V.;
RT   "A blood stage antigen of Plasmodium falciparum shares determinants with
RT   the sporozoite coat protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:5121-5125(1985).
CC   -!- MISCELLANEOUS: Although there are no authentic repeats in this antigen,
CC       there are a number of internal homologies (N-A-N-P) and (N-A-D-P), the
CC       first of these tetramers is the dominant repeat found in the CSP of
CC       P.falciparum and reacts with antibodies against CRA. It is possible
CC       that immune responses to CRA may act against the CSP also. The CRA is
CC       found in many parasitic strains.
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DR   EMBL; M11145; AAA29523.1; -; mRNA.
DR   PIR; A25780; A25780.
DR   AlphaFoldDB; P04923; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1121600; -.
DR   VEuPathDB; PlasmoDB:Pf7G8-2_000344300; -.
DR   VEuPathDB; PlasmoDB:Pf7G8_110025200; -.
DR   VEuPathDB; PlasmoDB:PfCD01_110027000; -.
DR   VEuPathDB; PlasmoDB:PfDd2_110024600; -.
DR   VEuPathDB; PlasmoDB:PfGA01_110025800; -.
DR   VEuPathDB; PlasmoDB:PfGB4_110028100; -.
DR   VEuPathDB; PlasmoDB:PfGN01_110026100; -.
DR   VEuPathDB; PlasmoDB:PfHB3_110024800; -.
DR   VEuPathDB; PlasmoDB:PfIT_110025900; -.
DR   VEuPathDB; PlasmoDB:PfKE01_110026100; -.
DR   VEuPathDB; PlasmoDB:PfKH01_110025700; -.
DR   VEuPathDB; PlasmoDB:PfKH02_110026600; -.
DR   VEuPathDB; PlasmoDB:PfML01_110026400; -.
DR   VEuPathDB; PlasmoDB:PfNF135_110024700; -.
DR   VEuPathDB; PlasmoDB:PfNF166_110025000; -.
DR   VEuPathDB; PlasmoDB:PfNF54_110025900; -.
DR   VEuPathDB; PlasmoDB:PfSD01_110024200; -.
DR   VEuPathDB; PlasmoDB:PfSN01_110024700; -.
DR   VEuPathDB; PlasmoDB:PfTG01_110026000; -.
PE   2: Evidence at transcript level;
KW   Malaria; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000305"
FT   CHAIN           17..162
FT                   /note="Circumsporozoite protein-related antigen"
FT                   /id="PRO_0000024517"
FT   REGION          24..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..155
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   162 AA;  17350 MW;  FB60C8250BC0B589 CRC64;
     MKILSVFFLA LFFIIFNKES LAEKTNKGTG SGVSSKKKNK KGSGEPLIDV HDLISDMIKK
     EEELVEVNKR KSKYKLATSV LAGLLGVVST VLLGGVGLVL YNTEKGRHPF KIGSSDPADN
     ANPDADSESN GEPNADPQVT AQDVTPEQPQ GDDNNLVSGP EH