ID   CRA_SALTY               Reviewed;         334 AA.
AC   P0A2P8; P21930;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Catabolite repressor/activator;
DE   AltName: Full=Fructose repressor;
GN   Name=cra; Synonyms=fruR; OrderedLocusNames=STM0118;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=1851954; DOI=10.1007/bf00273623;
RA   Jahreis K., Postma P.W., Lengeler J.W.;
RT   "Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12
RT   and Salmonella typhimurium LT2.";
RL   Mol. Gen. Genet. 226:332-336(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   PubMed=1805309; DOI=10.1016/0923-2508(91)90005-u;
RA   Vartak N.B., Reizer J., Reizer A., Gripp J.T., Groisman E.A., Wu L.-F.,
RA   Tomich J.M., Saier M.H. Jr.;
RT   "Sequence and evolution of the FruR protein of Salmonella typhimurium: a
RT   pleiotropic transcriptional regulatory protein possessing both activator
RT   and repressor functions which is homologous to the periplasmic ribose-
RT   binding protein.";
RL   Res. Microbiol. 142:951-963(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=10931352; DOI=10.1046/j.1365-2958.2000.02015.x;
RA   El Hanafi D., Bossi L.;
RT   "Activation and silencing of leu-500 promoter by transcription-induced DNA
RT   supercoiling in the Salmonella chromosome.";
RL   Mol. Microbiol. 37:583-594(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Global transcriptional regulator, which plays an important
CC       role in the regulation of carbon metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
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DR   EMBL; X55456; CAA39103.1; -; Genomic_DNA.
DR   EMBL; AF117227; AAF65176.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL19082.1; -; Genomic_DNA.
DR   PIR; S15941; S15941.
DR   RefSeq; NP_459123.1; NC_003197.2.
DR   RefSeq; WP_000762406.1; NC_003197.2.
DR   AlphaFoldDB; P0A2P8; -.
DR   SMR; P0A2P8; -.
DR   STRING; 99287.STM0118; -.
DR   PaxDb; P0A2P8; -.
DR   EnsemblBacteria; AAL19082; AAL19082; STM0118.
DR   GeneID; 1251636; -.
DR   KEGG; stm:STM0118; -.
DR   PATRIC; fig|99287.12.peg.124; -.
DR   HOGENOM; CLU_037628_6_0_6; -.
DR   OMA; NSRKAGY; -.
DR   PhylomeDB; P0A2P8; -.
DR   BioCyc; SENT99287:STM0118-MON; -.
DR   PHI-base; PHI:2672; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0009750; P:response to fructose; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR012781; Fruct_sucro_rep.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF00532; Peripla_BP_1; 1.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   TIGRFAMs; TIGR02417; fruct_sucro_rep; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..334
FT                   /note="Catabolite repressor/activator"
FT                   /id="PRO_0000107950"
FT   DOMAIN          1..58
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        3..22
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   334 AA;  38041 MW;  50394F35C185C6CE CRC64;
     MKLDEIARLA GVSRTTASYV INGKAKQYRV SDKTVEKVMA VVREHNYHPN AVAAGLRAGR
     TRSIGLVIPD LENTSYTRIA NYLERQARQR GYQLLIACSE DQPDNEMRCI EHLLQRQVDA
     IIVSTSLPPE HPFYQRWAND PFPIVALDRA LDREHFTSVV GADQDDAEML AEELRKFPAE
     TVLYLGALPE LSVSFLREQG FRTAWKDDPR EVNFLYANSY EREAAAQLFE KWLETHPMPQ
     ALFTTSFALL QGVMDVTLRR DGKLPSDLAI ATFGDHELLD FLQCPVLAVA QRHRDVAERV
     LEIVLASLDE PRKPKPGLTR IRRNLYRRGI LSRS