ID   CRB12_LITCT             Reviewed;         198 AA.
AC   Q91314;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Beta-crystallin A1-2;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=8619837; DOI=10.1006/bbrc.1996.0577;
RA   Lu S.-F., Pan F.-M., Chiou S.-H.;
RT   "Sequence analysis of four acidic beta-crystallin subunits of amphibian
RT   lenses: phylogenetic comparison between beta- and gamma-crystallins.";
RL   Biochem. Biophys. Res. Commun. 221:219-228(1996).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; X87760; CAA61034.1; -; mRNA.
DR   PIR; JC4705; S55512.
DR   AlphaFoldDB; Q91314; -.
DR   SMR; Q91314; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Repeat.
FT   CHAIN           1..198
FT                   /note="Beta-crystallin A1-2"
FT                   /id="PRO_0000057536"
FT   DOMAIN          14..53
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          54..100
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          107..148
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          149..197
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          1..13
FT                   /note="N-terminal arm"
FT   REGION          101..106
FT                   /note="Connecting peptide"
SQ   SEQUENCE   198 AA;  23096 MW;  52A09C6422C0C775 CRC64;
     MAQINPLPVP LGPWKITVYD QENFQGKRME FTSSCANIME CGFDNIRSLK VECGAWIGYE
     HTSFCGQQFV LERGEYPRWD AWSGSNAYHI ERLMSFRPIC SANHIESKLV IFEKENFVGP
     QWELCDDYPS LQAMGWGNNE VGSMKVQCGA WVCYQYPGYR GYQYILESDH HGGEYKHWRE
     WGSHAQTFQI QSIRRIQQ