ID   CRBA1_CHICK             Reviewed;         215 AA.
AC   P10042;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Beta-crystallin A3;
DE   AltName: Full=Beta-crystallin A1;
GN   Name=CRYBA1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3803920; DOI=10.1016/0378-1119(86)90248-9;
RA   Peterson C.A., Piatigorsky J.;
RT   "Preferential conservation of the globular domains of the beta A3/A1-
RT   crystallin polypeptide of the chicken eye lens.";
RL   Gene 45:139-147(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1353472; DOI=10.1016/0378-1119(92)90729-9;
RA   McDermott J.B., Peterson C.A., Piatigorsky J.;
RT   "Structure and lens expression of the gene encoding chicken beta A3/A1-
RT   crystallin.";
RL   Gene 117:193-200(1992).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=A3;
CC         IsoId=P10042-1; Sequence=Displayed;
CC       Name=A1;
CC         IsoId=P10042-2; Sequence=VSP_018712;
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA48612.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAA48725.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M15658; AAA48724.1; -; mRNA.
DR   EMBL; M15658; AAA48725.1; ALT_INIT; mRNA.
DR   EMBL; M84460; AAA48612.1; ALT_INIT; Genomic_DNA.
DR   EMBL; M84460; AAA48611.1; ALT_SEQ; Genomic_DNA.
DR   PIR; JC1231; JC1231.
DR   RefSeq; NP_990833.2; NM_205502.2. [P10042-1]
DR   RefSeq; XP_015151175.1; XM_015295689.1.
DR   RefSeq; XP_015151176.1; XM_015295690.1. [P10042-1]
DR   AlphaFoldDB; P10042; -.
DR   SMR; P10042; -.
DR   STRING; 9031.ENSGALP00000006416; -.
DR   PaxDb; P10042; -.
DR   PRIDE; P10042; -.
DR   Ensembl; ENSGALT00000006426; ENSGALP00000006416; ENSGALG00000004035. [P10042-1]
DR   GeneID; 396499; -.
DR   KEGG; gga:396499; -.
DR   CTD; 1411; -.
DR   VEuPathDB; HostDB:geneid_396499; -.
DR   eggNOG; ENOG502QSM0; Eukaryota.
DR   GeneTree; ENSGT00940000159685; -.
DR   HOGENOM; CLU_081883_0_0_1; -.
DR   InParanoid; P10042; -.
DR   OMA; IGRQWEM; -.
DR   OrthoDB; 1142622at2759; -.
DR   PhylomeDB; P10042; -.
DR   PRO; PR:P10042; -.
DR   Proteomes; UP000000539; Chromosome 19.
DR   Bgee; ENSGALG00000004035; Expressed in testis and 6 other tissues.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Alternative initiation; Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..215
FT                   /note="Beta-crystallin A3"
FT                   /id="PRO_0000006335"
FT   DOMAIN          31..70
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          71..117
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          124..165
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          166..214
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          1..30
FT                   /note="N-terminal arm"
FT   REGION          118..123
FT                   /note="Connecting peptide"
FT   VAR_SEQ         1..17
FT                   /note="Missing (in isoform A1)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_018712"
SQ   SEQUENCE   215 AA;  24749 MW;  69518AE6826B2921 CRC64;
     MGEAAVPPEL DTFPAAKMAQ TNPLPVPMGP WKITVYDQEN FQGKRMEFTS ACPNIMECGF
     DNIRSLKVEC GAWVGYEHTG FCGQQFILER GEYPRWDAWS GSNAYHIERL MSFRPVCSAN
     HKESKITVYE KDNFIGRQWE ISDDYPSLQA MGWANNEVGS MKIPCGAWVC YQYPGYRGYQ
     YVLEADHHGG DYKHWREWGS HAQTSQIQSI RRIQQ