ID   CRBA2_BOVIN             Reviewed;         197 AA.
AC   P26444;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Beta-crystallin A2;
DE   AltName: Full=Beta-A2 crystallin;
GN   Name=CRYBA2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=1874445; DOI=10.1016/0378-1119(91)90076-n;
RA   van Rens G.L., Driessen H.P.C., Nalini V., Slingsby C., de Jong W.W.,
RA   Bloemendal H.;
RT   "Isolation and characterization of cDNAs encoding beta A2- and beta A4-
RT   crystallins: heterologous interactions in the predicted beta A4-beta B2
RT   heterodimer.";
RL   Gene 102:179-188(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 134-197.
RC   TISSUE=Lens cortex;
RX   PubMed=6698025; DOI=10.1111/j.1432-1033.1984.tb08029.x;
RA   Berbers G.A.M., Hoekman W.A., Bloemendal H., de Jong W.W., Kleinschmidt T.,
RA   Braunitzer G.;
RT   "Homology between the primary structures of the major bovine beta-
RT   crystallin chains.";
RL   Eur. J. Biochem. 139:467-479(1984).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M60329; AAA30402.1; -; mRNA.
DR   PIR; JH0602; JH0602.
DR   RefSeq; NP_776949.1; NM_174524.2.
DR   AlphaFoldDB; P26444; -.
DR   SMR; P26444; -.
DR   STRING; 9913.ENSBTAP00000019735; -.
DR   PaxDb; P26444; -.
DR   Ensembl; ENSBTAT00000019735; ENSBTAP00000019735; ENSBTAG00000014819.
DR   GeneID; 282203; -.
DR   KEGG; bta:282203; -.
DR   CTD; 1412; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014819; -.
DR   VGNC; VGNC:27734; CRYBA2.
DR   eggNOG; ENOG502QVIR; Eukaryota.
DR   GeneTree; ENSGT00940000160306; -.
DR   HOGENOM; CLU_081883_0_0_1; -.
DR   InParanoid; P26444; -.
DR   OMA; SDCANIA; -.
DR   OrthoDB; 1142622at2759; -.
DR   TreeFam; TF331401; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000014819; Expressed in pigment epithelium of eye and 11 other tissues.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..197
FT                   /note="Beta-crystallin A2"
FT                   /id="PRO_0000057538"
FT   DOMAIN          12..52
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          53..99
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          106..147
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          148..196
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          1..11
FT                   /note="N-terminal arm"
FT   REGION          100..105
FT                   /note="Connecting peptide"
FT   CONFLICT        183..185
FT                   /note="QAH -> HAQ (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   197 AA;  22231 MW;  B673513089AC7DE9 CRC64;
     MSSAPAQGPA PASLTLWDEE DFQGRRCRLL SDCANIGERG GLRRVRSVKV ENGAWVAFEY
     PDFQGQQFIL EKGDYPRWSA WSGSAGHHSD QLLSFRPVLC ANHSDSRVTL FEGENFQGCK
     FELNDDYPSL PSMGWASKDV GSLKVSSGAW VAYQYPGYRG YQYVLERDHH SGEFRNYSEF
     GTQAHTGQLQ SIRRVQH