ID   CRBA2_CHICK             Reviewed;         196 AA.
AC   P55164;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Beta-crystallin A2;
DE   AltName: Full=Beta-A2 crystallin;
GN   Name=CRYBA2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Lens;
RX   PubMed=8674507; DOI=10.1006/exer.1996.0013;
RA   Duncan M.K., Banerjee-Basu S., McDermott J.B., Piatigorsky J.;
RT   "Sequence and expression of chicken beta A2- and beta B3-crystallins.";
RL   Exp. Eye Res. 62:111-119(1996).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; U28145; AAB08774.1; -; mRNA.
DR   RefSeq; NP_989510.1; NM_204179.1.
DR   AlphaFoldDB; P55164; -.
DR   SMR; P55164; -.
DR   STRING; 9031.ENSGALP00000018502; -.
DR   PaxDb; P55164; -.
DR   GeneID; 373999; -.
DR   KEGG; gga:373999; -.
DR   CTD; 1412; -.
DR   VEuPathDB; HostDB:geneid_373999; -.
DR   eggNOG; ENOG502QVIR; Eukaryota.
DR   InParanoid; P55164; -.
DR   OrthoDB; 1142622at2759; -.
DR   PhylomeDB; P55164; -.
DR   PRO; PR:P55164; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..196
FT                   /note="Beta-crystallin A2"
FT                   /id="PRO_0000057541"
FT   DOMAIN          12..51
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          52..98
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          105..146
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          147..195
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          1..11
FT                   /note="N-terminal arm"
FT   REGION          99..104
FT                   /note="Connecting peptide"
SQ   SEQUENCE   196 AA;  23004 MW;  C177575C41D3EE44 CRC64;
     MTSEAMDTLG QYKITVWEEE SFQGKRCEFL MECPSIMERG FRKIRSIKVE SGPWVGFEYP
     EYQGQQFILE KGDYPRWEAW SGNSGYRTEH LLSFRPVKCA NHNDSKAILY EAENFQGHKF
     ELSDDYPSLQ AMGWGNKEVA SIKVNAGAWV AYQYPGYRGY QYVLERDRQN GEFKKYSEYS
     SQAHTNQIQS IRRIQH