ID   CRBA2_MACFL             Reviewed;         197 AA.
AC   Q8HY68;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Beta-crystallin A2;
DE   AltName: Full=Beta-A2 crystallin;
GN   Name=CRYBA2;
OS   Macropus fuliginosus (Western gray kangaroo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Macropus.
OX   NCBI_TaxID=9316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RA   Wistow G.;
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; AY160974; AAN78173.1; -; mRNA.
DR   AlphaFoldDB; Q8HY68; -.
DR   SMR; Q8HY68; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Repeat.
FT   CHAIN           1..197
FT                   /note="Beta-crystallin A2"
FT                   /id="PRO_0000289603"
FT   DOMAIN          12..52
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          53..99
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          106..147
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          148..196
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          1..11
FT                   /note="N-terminal arm"
FT   REGION          100..105
FT                   /note="Connecting peptide"
SQ   SEQUENCE   197 AA;  22433 MW;  6FE6FDF485D3D4C2 CRC64;
     MSGTLSQGSS PARLTLWEEE NFQGRRCELM SDCSSIRELS GFRRVRSVKV ESGAWVGFEY
     PDFQGQQFIL EKGDYPRSTA WSGSSGYRTD QLLSFRPLLC ANHSDSRVTL YEGENFQGCK
     FELSDDYPSL PAMGWASKDV GSLKVTSGAW VGYQYPGFRG YQYVLEQDRH SGEFRKYSEF
     GTQAHTNQLQ SIRRVQH