CRBA2_MOUSE
ID CRBA2_MOUSE Reviewed; 197 AA.
AC Q9JJV1; Q540J7;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Beta-crystallin A2;
DE AltName: Full=Beta-A2 crystallin;
GN Name=Cryba2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Graw J.;
RT "Sequence analysis of beta-A2-, beta-A4- and beta-B3-crystallin cDNA
RT completes the identification of the members of this gene family in the
RT mouse.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC of beta-crystallin oligomers seems to be stabilized through
CC interactions between the N-terminal arms (By similarity).
CC {ECO:0000250}.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; AJ272227; CAB75585.1; -; mRNA.
DR EMBL; AK021374; BAB32389.1; -; mRNA.
DR EMBL; AY160973; AAN78172.1; -; mRNA.
DR EMBL; BC052746; AAH52746.1; -; mRNA.
DR EMBL; BC056989; AAH56989.1; -; mRNA.
DR CCDS; CCDS15059.1; -.
DR RefSeq; NP_067516.1; NM_021541.3.
DR RefSeq; XP_006495719.1; XM_006495656.3.
DR AlphaFoldDB; Q9JJV1; -.
DR SMR; Q9JJV1; -.
DR BioGRID; 198911; 2.
DR STRING; 10090.ENSMUSP00000006721; -.
DR iPTMnet; Q9JJV1; -.
DR PhosphoSitePlus; Q9JJV1; -.
DR MaxQB; Q9JJV1; -.
DR PaxDb; Q9JJV1; -.
DR PRIDE; Q9JJV1; -.
DR ProteomicsDB; 284115; -.
DR Antibodypedia; 34295; 52 antibodies from 15 providers.
DR DNASU; 12958; -.
DR Ensembl; ENSMUST00000006721; ENSMUSP00000006721; ENSMUSG00000006546.
DR GeneID; 12958; -.
DR KEGG; mmu:12958; -.
DR UCSC; uc007bni.2; mouse.
DR CTD; 1412; -.
DR MGI; MGI:104336; Cryba2.
DR VEuPathDB; HostDB:ENSMUSG00000006546; -.
DR eggNOG; ENOG502QVIR; Eukaryota.
DR GeneTree; ENSGT00940000160306; -.
DR HOGENOM; CLU_081883_0_0_1; -.
DR InParanoid; Q9JJV1; -.
DR OMA; SDCANIA; -.
DR OrthoDB; 1142622at2759; -.
DR PhylomeDB; Q9JJV1; -.
DR TreeFam; TF331401; -.
DR BioGRID-ORCS; 12958; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Cryba2; mouse.
DR PRO; PR:Q9JJV1; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9JJV1; protein.
DR Bgee; ENSMUSG00000006546; Expressed in lens of camera-type eye and 51 other tissues.
DR ExpressionAtlas; Q9JJV1; baseline and differential.
DR Genevisible; Q9JJV1; MM.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IMP:MGI.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 2: Evidence at transcript level;
KW Eye lens protein; Reference proteome; Repeat.
FT CHAIN 1..197
FT /note="Beta-crystallin A2"
FT /id="PRO_0000057540"
FT DOMAIN 12..52
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 53..99
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 106..147
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 148..196
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 1..11
FT /note="N-terminal arm"
FT REGION 100..105
FT /note="Connecting peptide"
SQ SEQUENCE 197 AA; 22237 MW; A0C8DE0730AA18D8 CRC64;
MSSAPAPGSA PVCLTLWDEE DFQGRRCRLL SDCANVCERG ALRRVRSVKV ENGAWVAFEY
PDFQGQQFIL EKGDYPCWSA WSGSSGHHSN QLLSFRPVLC ANHSDSRVTL FEGENFQGCK
FELSDDYPSL PSMGWTSKDV GSLKVSSGAW VAYQYPGYRG YQYVLERDRH SGEFRTYSDF
GTQAHTGQLQ SIRRVQH
