ID   CRBA2_RABIT             Reviewed;         197 AA.
AC   A4L9I9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Beta-crystallin A2;
DE   AltName: Full=Beta-A2 crystallin;
GN   Name=CRYBA2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RA   Wistow G.;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; EF457886; ABO41862.1; -; mRNA.
DR   RefSeq; NP_001093440.1; NM_001099970.1.
DR   AlphaFoldDB; A4L9I9; -.
DR   SMR; A4L9I9; -.
DR   STRING; 9986.ENSOCUP00000000183; -.
DR   Ensembl; ENSOCUT00000000206; ENSOCUP00000000183; ENSOCUG00000000206.
DR   GeneID; 100101619; -.
DR   KEGG; ocu:100101619; -.
DR   CTD; 1412; -.
DR   eggNOG; ENOG502QVIR; Eukaryota.
DR   GeneTree; ENSGT00940000160306; -.
DR   HOGENOM; CLU_081883_0_0_1; -.
DR   InParanoid; A4L9I9; -.
DR   OMA; SDCANIA; -.
DR   OrthoDB; 1142622at2759; -.
DR   TreeFam; TF331401; -.
DR   Proteomes; UP000001811; Chromosome 7.
DR   Bgee; ENSOCUG00000000206; Expressed in embryo and 2 other tissues.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..197
FT                   /note="Beta-crystallin A2"
FT                   /id="PRO_0000289611"
FT   DOMAIN          12..52
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          53..99
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          106..147
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          148..196
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          1..11
FT                   /note="N-terminal arm"
FT   REGION          100..105
FT                   /note="Connecting peptide"
SQ   SEQUENCE   197 AA;  22213 MW;  A011C40966822804 CRC64;
     MSSASAPGPA PACLTLWDEE DFQGRRCRLL SDCANVGERG GLRRVRSVKV ENGAWVAFEY
     PDFQGQQFIL EKGDYPRWSA WSGSSGHHSN QLLSFRPVLC ANHSDSRVTL FEGENFQGCK
     FELSDDYPSL PSMGWASKEV GSLKVSSGAW VAYQYPGYRG YQYVLERDRH SGEFRNYSEF
     GTQAHTGQLQ SIRRVQH