CRBA4_BOVIN
ID CRBA4_BOVIN Reviewed; 210 AA.
AC P11842;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Beta-crystallin A4;
DE AltName: Full=Beta-A4 crystallin;
GN Name=CRYBA4;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lens;
RX PubMed=1874445; DOI=10.1016/0378-1119(91)90076-n;
RA van Rens G.L., Driessen H.P.C., Nalini V., Slingsby C., de Jong W.W.,
RA Bloemendal H.;
RT "Isolation and characterization of cDNAs encoding beta A2- and beta A4-
RT crystallins: heterologous interactions in the predicted beta A4-beta B2
RT heterodimer.";
RL Gene 102:179-188(1991).
RN [2]
RP PROTEIN SEQUENCE OF 147-210.
RC TISSUE=Lens cortex;
RX PubMed=6698025; DOI=10.1111/j.1432-1033.1984.tb08029.x;
RA Berbers G.A.M., Hoekman W.A., Bloemendal H., de Jong W.W., Kleinschmidt T.,
RA Braunitzer G.;
RT "Homology between the primary structures of the major bovine beta-
RT crystallin chains.";
RL Eur. J. Biochem. 139:467-479(1984).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC of beta-crystallin oligomers seems to be stabilized through
CC interactions between the N-terminal arms (By similarity).
CC {ECO:0000250}.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; M60328; AAA30403.1; -; mRNA.
DR PIR; JH0603; JH0603.
DR RefSeq; NP_776950.1; NM_174525.2.
DR AlphaFoldDB; P11842; -.
DR SMR; P11842; -.
DR STRING; 9913.ENSBTAP00000025674; -.
DR PaxDb; P11842; -.
DR GeneID; 282204; -.
DR KEGG; bta:282204; -.
DR CTD; 1413; -.
DR eggNOG; ENOG502QTF8; Eukaryota.
DR HOGENOM; CLU_081883_0_0_1; -.
DR InParanoid; P11842; -.
DR OrthoDB; 1142622at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR033342; CRYBA4.
DR InterPro; IPR011024; G_crystallin-like.
DR PANTHER; PTHR11818:SF19; PTHR11818:SF19; 1.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Eye lens protein; Reference proteome; Repeat.
FT CHAIN 1..210
FT /note="Beta-crystallin A4"
FT /id="PRO_0000057544"
FT DOMAIN 26..65
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 66..112
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 119..160
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 161..209
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 1..25
FT /note="N-terminal arm"
FT REGION 113..118
FT /note="Connecting peptide"
SQ SEQUENCE 210 AA; 23860 MW; 8264CDB9B712622B CRC64;
MSGMFSGSIS ETSGMSLQCT KSAGHWKIVV WDEEGFQGRR HEFTAECPSV LELGFETVRS
LKVLSGAWVG FEHAGFQGQQ YVLERGEYPS WDAWSGNTSY PAERLTSFRP VACANHRDSR
LTIFEQENFL GRKGELSDDY PSLQAMGWDG NEVGSFHVHS GAWVCSQFPG YRGFQYVLEC
DHHSGDYKHF REWGSHAQTF QVQSIRRIQQ
