ID   CRBA4_CANLF             Reviewed;         196 AA.
AC   A2ICR5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Beta-crystallin A4;
DE   AltName: Full=Beta-A4 crystallin;
GN   Name=CRYBA4;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RA   Wistow G.;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; EF195231; ABM69250.1; -; mRNA.
DR   RefSeq; NP_001074366.1; NM_001080897.1.
DR   RefSeq; XP_005636079.1; XM_005636022.2.
DR   RefSeq; XP_005636080.1; XM_005636023.2.
DR   AlphaFoldDB; A2ICR5; -.
DR   SMR; A2ICR5; -.
DR   STRING; 9612.ENSCAFP00000017377; -.
DR   PaxDb; A2ICR5; -.
DR   Ensembl; ENSCAFT00030047203; ENSCAFP00030041269; ENSCAFG00030025556.
DR   Ensembl; ENSCAFT00040047717; ENSCAFP00040041656; ENSCAFG00040025567.
DR   Ensembl; ENSCAFT00845052778; ENSCAFP00845041436; ENSCAFG00845029784.
DR   GeneID; 486334; -.
DR   KEGG; cfa:486334; -.
DR   CTD; 1413; -.
DR   VEuPathDB; HostDB:ENSCAFG00845029784; -.
DR   eggNOG; ENOG502QTF8; Eukaryota.
DR   GeneTree; ENSGT00940000160372; -.
DR   InParanoid; A2ICR5; -.
DR   OrthoDB; 1142622at2759; -.
DR   Proteomes; UP000002254; Chromosome 26.
DR   Bgee; ENSCAFG00000011809; Expressed in retina and 47 other tissues.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR   GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR033342; CRYBA4.
DR   InterPro; IPR011024; G_crystallin-like.
DR   PANTHER; PTHR11818:SF19; PTHR11818:SF19; 1.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Acetylation; Eye lens protein; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P53673"
FT   CHAIN           2..196
FT                   /note="Beta-crystallin A4"
FT                   /id="PRO_0000289575"
FT   DOMAIN          12..51
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          52..98
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          105..146
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          147..195
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          2..11
FT                   /note="N-terminal arm"
FT   REGION          99..104
FT                   /note="Connecting peptide"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P53673"
SQ   SEQUENCE   196 AA;  22443 MW;  BA50C21FC2D9397D CRC64;
     MTLQCTKSAG HWKIVVWDEE GFQGRRHEFT AECPSVLELG FETVRSLKVL SGAWVGFEHA
     GFQGQQYVLE RGEYPSWDAW SGNTAYPADR LTSFRPVACA NHRDSRLTIF EQENFLGKKG
     ELSDDYPSLQ AMGWDGNEVG SFHVHSGAWV CSQFPGYRGF QYVLECDHHS GDYKHFREWG
     SHAQTFQVQS VRRIQQ