ID   CRBA4_CHICK             Reviewed;         196 AA.
AC   P49152;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Beta-crystallin A4;
DE   AltName: Full=Beta-A4 crystallin;
GN   Name=CRYBA4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=White leghorn; TISSUE=Lens;
RX   PubMed=7557428; DOI=10.1016/0378-1119(95)00363-b;
RA   Duncan M.K., Haynes J.I. II, Piatigorsky J.;
RT   "The chicken beta A4- and beta B1-crystallin-encoding genes are tightly
RT   linked.";
RL   Gene 162:189-196(1995).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; U18261; AAB60607.1; -; mRNA.
DR   EMBL; U18260; AAA62669.1; -; Genomic_DNA.
DR   PIR; JC4257; JC4257.
DR   RefSeq; NP_989509.1; NM_204178.1.
DR   AlphaFoldDB; P49152; -.
DR   SMR; P49152; -.
DR   STRING; 9031.ENSGALP00000009025; -.
DR   PaxDb; P49152; -.
DR   GeneID; 373998; -.
DR   KEGG; gga:373998; -.
DR   CTD; 1413; -.
DR   VEuPathDB; HostDB:geneid_373998; -.
DR   eggNOG; ENOG502QTF8; Eukaryota.
DR   InParanoid; P49152; -.
DR   OrthoDB; 1142622at2759; -.
DR   PhylomeDB; P49152; -.
DR   PRO; PR:P49152; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR033342; CRYBA4.
DR   InterPro; IPR011024; G_crystallin-like.
DR   PANTHER; PTHR11818:SF19; PTHR11818:SF19; 1.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..196
FT                   /note="Beta-crystallin A4"
FT                   /id="PRO_0000057548"
FT   DOMAIN          12..51
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          52..98
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          105..146
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          147..195
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          1..11
FT                   /note="N-terminal arm"
FT   REGION          99..104
FT                   /note="Connecting peptide"
FT   VARIANT         103
FT                   /note="G -> R"
SQ   SEQUENCE   196 AA;  22416 MW;  BC0787DC8FCBC8D5 CRC64;
     MIQRRRPSSG LWKIVVWDEP FFQGKRHEFT TDCYSTPERG FSTVRSFRIE SGAWVGFEHC
     GFQGQQFVLE RGEYPCWEAW SGSNAYHVDR MSSFRPITCA VHGRSQLLLF EQENFQGRRG
     ELSDDCPSLP ALGWGGSAVG SFLVCSGAWV CSQYPGYRGF QYLLESDTHA GEYKHVREWG
     SHAQTGQVQS IRRVQQ