CRBA4_MOUSE
ID CRBA4_MOUSE Reviewed; 196 AA.
AC Q9JJV0;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Beta-crystallin A4;
DE AltName: Full=Beta-A4 crystallin;
GN Name=Cryba4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Graw J.;
RT "Sequence analysis of beta-A2-, beta-A4- and beta-B3-crystallin cDNA
RT completes the identification of the members of this gene family in the
RT mouse.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC of beta-crystallin oligomers seems to be stabilized through
CC interactions between the N-terminal arms (By similarity).
CC {ECO:0000250}.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; AJ272228; CAB75586.1; -; mRNA.
DR EMBL; BC056444; AAH56444.1; -; mRNA.
DR EMBL; BC058703; AAH58703.1; -; mRNA.
DR CCDS; CCDS19536.1; -.
DR RefSeq; NP_001299813.1; NM_001312884.1.
DR RefSeq; NP_067326.1; NM_021351.2.
DR AlphaFoldDB; Q9JJV0; -.
DR SMR; Q9JJV0; -.
DR BioGRID; 198912; 1.
DR STRING; 10090.ENSMUSP00000108004; -.
DR PhosphoSitePlus; Q9JJV0; -.
DR MaxQB; Q9JJV0; -.
DR PaxDb; Q9JJV0; -.
DR PRIDE; Q9JJV0; -.
DR ProteomicsDB; 284116; -.
DR Antibodypedia; 24295; 141 antibodies from 22 providers.
DR DNASU; 12959; -.
DR Ensembl; ENSMUST00000086629; ENSMUSP00000083826; ENSMUSG00000066975.
DR Ensembl; ENSMUST00000112385; ENSMUSP00000108004; ENSMUSG00000066975.
DR GeneID; 12959; -.
DR KEGG; mmu:12959; -.
DR UCSC; uc008yst.1; mouse.
DR CTD; 1413; -.
DR MGI; MGI:102716; Cryba4.
DR VEuPathDB; HostDB:ENSMUSG00000066975; -.
DR eggNOG; ENOG502QTF8; Eukaryota.
DR GeneTree; ENSGT00940000160372; -.
DR InParanoid; Q9JJV0; -.
DR OMA; GEYPSWE; -.
DR OrthoDB; 1142622at2759; -.
DR PhylomeDB; Q9JJV0; -.
DR TreeFam; TF331401; -.
DR BioGRID-ORCS; 12959; 4 hits in 75 CRISPR screens.
DR ChiTaRS; Cryba4; mouse.
DR PRO; PR:Q9JJV0; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9JJV0; protein.
DR Bgee; ENSMUSG00000066975; Expressed in lens of camera-type eye and 48 other tissues.
DR ExpressionAtlas; Q9JJV0; baseline and differential.
DR Genevisible; Q9JJV0; MM.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0005212; F:structural constituent of eye lens; ISO:MGI.
DR GO; GO:0043010; P:camera-type eye development; ISO:MGI.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; ISO:MGI.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR033342; CRYBA4.
DR InterPro; IPR011024; G_crystallin-like.
DR PANTHER; PTHR11818:SF19; PTHR11818:SF19; 1.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 2: Evidence at transcript level;
KW Acetylation; Eye lens protein; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P53673"
FT CHAIN 2..196
FT /note="Beta-crystallin A4"
FT /id="PRO_0000057546"
FT DOMAIN 12..51
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 52..98
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 105..146
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 147..195
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 2..11
FT /note="N-terminal arm"
FT REGION 99..104
FT /note="Connecting peptide"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0000250|UniProtKB:P53673"
SQ SEQUENCE 196 AA; 22469 MW; 5911B1C784DD253B CRC64;
MTLQCTKSAG HWRMVVWDEE GFQGRRHEFT AECPSVLELG FETVRSLKVL SGAWVGFEHA
GFQGQQYVLE RGDYPGWDAW GGNTAYPAER LTSFRPVACA NHRDSRLTIF EQENFLGRKG
ELNDDYPSLQ AMGWDGTEVG SFHVQSGAWV CSQFPGYRGF QYILESDHHS GDYKHFREWG
SHAHTFQVQS VRRIQQ
