CRBB1_CHICK
ID CRBB1_CHICK Reviewed; 238 AA.
AC P07530; Q90614;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Beta-crystallin B1;
DE AltName: Full=Beta-35;
DE AltName: Full=Beta-B1 crystallin;
GN Name=CRYBB1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3753603; DOI=10.1016/s0021-9258(17)36194-x;
RA Hejtmancik J.F., Thompson M.A., Wistow G., Piatigorsky J.;
RT "cDNA and deduced protein sequence for the beta B1-crystallin polypeptide
RT of the chicken lens. Conservation of the PAPA sequence.";
RL J. Biol. Chem. 261:982-987(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7893762; DOI=10.1016/0167-4781(94)00223-p;
RA Duncan M.K., Roth H.J., Thompson M., Kantorow M., Piatigorsky J.;
RT "Chicken beta B1 crystallin: gene sequence and evidence for functional
RT conservation of promoter activity between chicken and mouse.";
RL Biochim. Biophys. Acta 1261:68-76(1995).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC of beta-crystallin oligomers seems to be stabilized through
CC interactions between the N-terminal arms (By similarity).
CC {ECO:0000250}.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; M11619; AAA48723.1; -; mRNA.
DR EMBL; U09951; AAA78808.2; -; Genomic_DNA.
DR PIR; S53533; CYCHB1.
DR RefSeq; NP_989511.1; NM_204180.1.
DR AlphaFoldDB; P07530; -.
DR SMR; P07530; -.
DR STRING; 9031.ENSGALP00000009017; -.
DR PaxDb; P07530; -.
DR Ensembl; ENSGALT00000009031; ENSGALP00000009017; ENSGALG00000005630.
DR Ensembl; ENSGALT00000107010; ENSGALP00000069787; ENSGALG00000005630.
DR GeneID; 374000; -.
DR KEGG; gga:374000; -.
DR CTD; 1414; -.
DR VEuPathDB; HostDB:geneid_374000; -.
DR eggNOG; ENOG502QTJT; Eukaryota.
DR GeneTree; ENSGT00940000160516; -.
DR HOGENOM; CLU_081883_0_1_1; -.
DR InParanoid; P07530; -.
DR OMA; AQEHKIC; -.
DR OrthoDB; 1237607at2759; -.
DR PhylomeDB; P07530; -.
DR TreeFam; TF331401; -.
DR PRO; PR:P07530; -.
DR Proteomes; UP000000539; Chromosome 15.
DR Bgee; ENSGALG00000005630; Expressed in brain and 1 other tissue.
DR ExpressionAtlas; P07530; baseline and differential.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR033059; CRYBB1.
DR InterPro; IPR011024; G_crystallin-like.
DR PANTHER; PTHR11818:SF12; PTHR11818:SF12; 1.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 2: Evidence at transcript level;
KW Eye lens protein; Reference proteome; Repeat.
FT CHAIN 1..238
FT /note="Beta-crystallin B1"
FT /id="PRO_0000057551"
FT DOMAIN 46..85
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 86..130
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 136..177
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 178..220
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 1..45
FT /note="N-terminal arm"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..135
FT /note="Connecting peptide"
FT REGION 222..238
FT /note="C-terminal arm"
SQ SEQUENCE 238 AA; 27267 MW; 16E11B998C66055A CRC64;
MSETTKTAAP GQAAEDKEKA APAPAPSSDP TPVTNSKGEE PSTEAFRIVI FEQENFQGRQ
MEFTSECLNL ADCGFDRVRS VIVSSGPWVA YEQANMRGEM FILEKGEYPR WDTWSSSYRS
DCFMSMRPIR MEAEDHKISL YESADFKGNK MDIQEDDVPS LWAYGFCDRV GSVKVPSGTW
VGYQYPGYRG YQYLFETGDF RHWNEWCAFQ PQIQSIRRIR DMQWDQKGTF VTPEAPSN
