ID   CRBB2_CANLF             Reviewed;         205 AA.
AC   Q2LEC2;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Beta-crystallin B2;
DE   AltName: Full=Beta-B2 crystallin;
DE   AltName: Full=Beta-crystallin Bp;
GN   Name=CRYBB2;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RA   Wistow G.;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; DQ324463; ABC59315.1; -; mRNA.
DR   RefSeq; NP_001041578.1; NM_001048113.1.
DR   AlphaFoldDB; Q2LEC2; -.
DR   SMR; Q2LEC2; -.
DR   STRING; 9612.ENSCAFP00000017026; -.
DR   PaxDb; Q2LEC2; -.
DR   Ensembl; ENSCAFT00030048286; ENSCAFP00030042249; ENSCAFG00030026106.
DR   Ensembl; ENSCAFT00040046977; ENSCAFP00040041009; ENSCAFG00040025194.
DR   Ensembl; ENSCAFT00845049384; ENSCAFP00845038748; ENSCAFG00845027963.
DR   GeneID; 486326; -.
DR   KEGG; cfa:486326; -.
DR   CTD; 1415; -.
DR   VEuPathDB; HostDB:ENSCAFG00845027963; -.
DR   eggNOG; ENOG502QVM6; Eukaryota.
DR   GeneTree; ENSGT00940000160048; -.
DR   HOGENOM; CLU_081883_0_1_1; -.
DR   InParanoid; Q2LEC2; -.
DR   OMA; TWVAYQY; -.
DR   OrthoDB; 1237607at2759; -.
DR   TreeFam; TF331401; -.
DR   Proteomes; UP000002254; Chromosome 26.
DR   Bgee; ENSCAFG00000023827; Expressed in tongue and 3 other tissues.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR033058; CRYBB2.
DR   InterPro; IPR011024; G_crystallin-like.
DR   PANTHER; PTHR11818:SF11; PTHR11818:SF11; 1.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Acetylation; Eye lens protein; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P02522"
FT   CHAIN           2..205
FT                   /note="Beta-crystallin B2"
FT                   /id="PRO_0000289593"
FT   DOMAIN          17..56
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          57..101
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          107..148
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          149..191
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          2..16
FT                   /note="N-terminal arm"
FT   REGION          102..106
FT                   /note="Connecting peptide"
FT   REGION          193..205
FT                   /note="C-terminal arm"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P02522"
SQ   SEQUENCE   205 AA;  23333 MW;  35020BEFB7D068F9 CRC64;
     MASDHQTQAG KPQPLNPKII IFEQENFQGH SHELSGPCPN LKETGVEKAG SVLVQAGPWV
     GYEQANCKGE QFVFEKGEYP RWDSWTSSRR TDSLSSLRPI KVDSQEHKII LYENPNFTGK
     KMEIIDDDVP SFHAHGYQEK VSSVRVQSGT WVGYQYPGYR GLQYLLEKGD YKDSGDFGAP
     HPQVQSVRRI RDMQWHQRGA FHPSN