CRBB2_CHICK
ID CRBB2_CHICK Reviewed; 219 AA.
AC Q05714;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Beta-crystallin B2;
DE AltName: Full=Beta-B2 crystallin;
DE AltName: Full=Beta-crystallin Bp;
GN Name=CRYBB2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lens;
RX PubMed=1283129; DOI=10.1016/0014-4835(92)90014-j;
RA Sawada K., Agata K., Eguchi G.;
RT "Crystallin gene expression in the process of lentoidogenesis in cultures
RT of chicken lens epithelial cells.";
RL Exp. Eye Res. 55:879-887(1992).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC of beta-crystallin oligomers seems to be stabilized through
CC interactions between the N-terminal arms (By similarity).
CC {ECO:0000250}.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; S52930; AAB25042.1; -; mRNA.
DR PIR; B49181; B49181.
DR AlphaFoldDB; Q05714; -.
DR SMR; Q05714; -.
DR STRING; 9031.ENSGALP00000037856; -.
DR VEuPathDB; HostDB:geneid_396088; -.
DR eggNOG; ENOG502QVM6; Eukaryota.
DR InParanoid; Q05714; -.
DR PhylomeDB; Q05714; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR033058; CRYBB2.
DR InterPro; IPR011024; G_crystallin-like.
DR PANTHER; PTHR11818:SF11; PTHR11818:SF11; 1.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 2: Evidence at transcript level;
KW Acetylation; Eye lens protein; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P02522"
FT CHAIN 2..219
FT /note="Beta-crystallin B2"
FT /id="PRO_0000057557"
FT DOMAIN 17..56
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 57..101
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 121..162
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 163..205
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 2..16
FT /note="N-terminal arm"
FT REGION 102..120
FT /note="Connecting peptide"
FT REGION 207..219
FT /note="C-terminal arm"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P02522"
SQ SEQUENCE 219 AA; 25060 MW; 8DF73D2952F3DC1F CRC64;
MASEHQMPAS KQQPASPNIA IFEQENFQGR CHELSGACPN LKDAGVDKVG SILVHSGPWV
GYEQASCKGE QFVFEKGEYP RWDSWTNSRR SDSITSLRPI KVVRAPRQPL PTRQTKDSQE
HKIVLYENPS FTGKKIEIID DDVPSFHAHG YQEKVSSVRV QSGTWVGYQY PGYRGYQYLF
EKGDYKDSSE FGAQHPQIQS VRRIRDMQWH QRGAYHPSN
