ID   CRBB2_MESAU             Reviewed;         205 AA.
AC   P62698; P19942; P26775;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Beta-crystallin B2;
DE   AltName: Full=Beta-B2 crystallin;
DE   AltName: Full=Beta-crystallin Bp;
GN   Name=CRYBB2;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=8863746; DOI=10.1016/0378-1119(96)00256-9;
RA   Zarbalis K., Chatterjee B., Loester J., Werner T., Graw J.;
RT   "Sequence analysis of the beta B2-crystallin cDNA of hamster containing a
RT   domain conserved among vertebrates.";
RL   Gene 174:181-184(1996).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X94745; CAA64371.1; -; mRNA.
DR   PIR; JC4964; JC4964.
DR   RefSeq; NP_001268306.1; NM_001281377.1.
DR   AlphaFoldDB; P62698; -.
DR   SMR; P62698; -.
DR   STRING; 10036.XP_005078977.1; -.
DR   GeneID; 101842717; -.
DR   CTD; 1415; -.
DR   eggNOG; ENOG502QVM6; Eukaryota.
DR   OrthoDB; 1237607at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR   GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR033058; CRYBB2.
DR   InterPro; IPR011024; G_crystallin-like.
DR   PANTHER; PTHR11818:SF11; PTHR11818:SF11; 1.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Acetylation; Eye lens protein; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P02522"
FT   CHAIN           2..205
FT                   /note="Beta-crystallin B2"
FT                   /id="PRO_0000057554"
FT   DOMAIN          17..56
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          57..101
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          107..148
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          149..191
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          2..16
FT                   /note="N-terminal arm"
FT   REGION          102..106
FT                   /note="Connecting peptide"
FT   REGION          193..205
FT                   /note="C-terminal arm"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P02522"
SQ   SEQUENCE   205 AA;  23381 MW;  73B4C4789D79B9FA CRC64;
     MASDHQTQAG KPQPLNPKII IFEQENFQGH SHELSGPCPN LKETGMEKAG SVLVQAGPWV
     GYEQANCKGE QFVFEKGEYP RWDSWTSSRR TDSLSSLRPI KVDSQEHKII LYENPNFTGK
     KMEIVDDDVP SFHAHGYQEK VSSVRVQSGT WVGYQYPGYR GLQYLLEKGD YKDNSDFGAP
     HPQVQSVRRI RDMQWHQRGA FHPSS