CRBB2_MOUSE
ID CRBB2_MOUSE Reviewed; 205 AA.
AC P62696; P19942; P26775; Q0VGT6;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Beta-crystallin B2;
DE AltName: Full=Beta-B2 crystallin;
DE AltName: Full=Beta-crystallin Bp;
GN Name=Crybb2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Swiss Webster; TISSUE=Lens;
RX PubMed=1707874; DOI=10.1016/s0021-9258(20)89562-3;
RA Chambers C., Russell P.;
RT "Deletion mutation in an eye lens beta-crystallin. An animal model for
RT inherited cataracts.";
RL J. Biol. Chem. 266:6742-6746(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC of beta-crystallin oligomers seems to be stabilized through
CC interactions between the N-terminal arms (By similarity).
CC {ECO:0000250}.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; M60559; AAA21181.1; -; mRNA.
DR EMBL; AK020891; BAB32243.1; -; mRNA.
DR EMBL; BC085185; AAH85185.1; -; mRNA.
DR CCDS; CCDS19546.1; -.
DR PIR; A39757; A39757.
DR RefSeq; NP_031799.1; NM_007773.4.
DR RefSeq; XP_006534822.1; XM_006534759.1.
DR RefSeq; XP_006534823.1; XM_006534760.1.
DR RefSeq; XP_017176141.1; XM_017320652.1.
DR PDB; 1E7N; X-ray; 2.35 A; A/B=2-104.
DR PDBsum; 1E7N; -.
DR AlphaFoldDB; P62696; -.
DR SMR; P62696; -.
DR BioGRID; 198914; 1.
DR STRING; 10090.ENSMUSP00000107955; -.
DR iPTMnet; P62696; -.
DR PhosphoSitePlus; P62696; -.
DR MaxQB; P62696; -.
DR PaxDb; P62696; -.
DR PRIDE; P62696; -.
DR ProteomicsDB; 284117; -.
DR Antibodypedia; 35320; 127 antibodies from 24 providers.
DR DNASU; 12961; -.
DR Ensembl; ENSMUST00000031295; ENSMUSP00000031295; ENSMUSG00000042240.
DR Ensembl; ENSMUST00000112336; ENSMUSP00000107955; ENSMUSG00000042240.
DR GeneID; 12961; -.
DR KEGG; mmu:12961; -.
DR UCSC; uc008ytx.2; mouse.
DR CTD; 1415; -.
DR MGI; MGI:88519; Crybb2.
DR VEuPathDB; HostDB:ENSMUSG00000042240; -.
DR eggNOG; ENOG502QVM6; Eukaryota.
DR GeneTree; ENSGT00940000160048; -.
DR HOGENOM; CLU_081883_0_1_1; -.
DR InParanoid; P62696; -.
DR OMA; TWVAYQY; -.
DR OrthoDB; 1237607at2759; -.
DR PhylomeDB; P62696; -.
DR TreeFam; TF331401; -.
DR BioGRID-ORCS; 12961; 1 hit in 58 CRISPR screens.
DR EvolutionaryTrace; P62696; -.
DR PRO; PR:P62696; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P62696; protein.
DR Bgee; ENSMUSG00000042240; Expressed in epithelium of lens and 19 other tissues.
DR Genevisible; P62696; MM.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0005212; F:structural constituent of eye lens; IDA:MGI.
DR GO; GO:0043010; P:camera-type eye development; IMP:MGI.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IMP:MGI.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR033058; CRYBB2.
DR InterPro; IPR011024; G_crystallin-like.
DR PANTHER; PTHR11818:SF11; PTHR11818:SF11; 1.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Eye lens protein; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P02522"
FT CHAIN 2..205
FT /note="Beta-crystallin B2"
FT /id="PRO_0000057555"
FT DOMAIN 17..56
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 57..101
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 107..148
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 149..191
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 2..16
FT /note="N-terminal arm"
FT REGION 102..106
FT /note="Connecting peptide"
FT REGION 193..205
FT /note="C-terminal arm"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P02522"
SQ SEQUENCE 205 AA; 23381 MW; 73B4C4789D79B9FA CRC64;
MASDHQTQAG KPQPLNPKII IFEQENFQGH SHELSGPCPN LKETGMEKAG SVLVQAGPWV
GYEQANCKGE QFVFEKGEYP RWDSWTSSRR TDSLSSLRPI KVDSQEHKII LYENPNFTGK
KMEIVDDDVP SFHAHGYQEK VSSVRVQSGT WVGYQYPGYR GLQYLLEKGD YKDNSDFGAP
HPQVQSVRRI RDMQWHQRGA FHPSS
