ID   CRBB2_RABIT             Reviewed;         205 AA.
AC   A2IBH5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Beta-crystallin B2;
DE   AltName: Full=Beta-B2 crystallin;
DE   AltName: Full=Beta-crystallin Bp;
GN   Name=CRYBB2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RA   Wistow G.;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; EF187821; ABM74184.1; -; mRNA.
DR   RefSeq; NP_001082786.1; NM_001089317.1.
DR   AlphaFoldDB; A2IBH5; -.
DR   SMR; A2IBH5; -.
DR   STRING; 9986.ENSOCUP00000013827; -.
DR   Ensembl; ENSOCUT00000016086; ENSOCUP00000013827; ENSOCUG00000016082.
DR   GeneID; 100037715; -.
DR   KEGG; ocu:100037715; -.
DR   CTD; 1415; -.
DR   eggNOG; ENOG502QVM6; Eukaryota.
DR   GeneTree; ENSGT00940000160048; -.
DR   HOGENOM; CLU_081883_0_1_1; -.
DR   InParanoid; A2IBH5; -.
DR   OMA; TWVAYQY; -.
DR   OrthoDB; 1237607at2759; -.
DR   TreeFam; TF331401; -.
DR   Proteomes; UP000001811; Unplaced.
DR   Bgee; ENSOCUG00000016082; Expressed in embryo and 1 other tissue.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR033058; CRYBB2.
DR   InterPro; IPR011024; G_crystallin-like.
DR   PANTHER; PTHR11818:SF11; PTHR11818:SF11; 1.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Acetylation; Eye lens protein; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P02522"
FT   CHAIN           2..205
FT                   /note="Beta-crystallin B2"
FT                   /id="PRO_0000289605"
FT   DOMAIN          17..56
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          57..101
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          107..148
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          149..191
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          2..16
FT                   /note="N-terminal arm"
FT   REGION          102..106
FT                   /note="Connecting peptide"
FT   REGION          193..205
FT                   /note="C-terminal arm"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P02522"
SQ   SEQUENCE   205 AA;  23404 MW;  5040CF9A6F9A6501 CRC64;
     MASDHQTQAG KPQPLNPKII IFEQENFQGH SHELNGPCPN LKETGVEKAG SVLVQAGPWV
     GYEQANCKGE QFVFEKGEYP RWDSWTSSRR TDSLSSLRPI KVDSQEHKII LYENPNFTGK
     KMEIIDDDVP SFHAHGYQEK VSSVRVQSGT WVGYQYPGYR GLQYLLEKGD YKDSSDFGAP
     HPQVQSVRRI RDMQWHQRGA FHPTN