ID   CRBB3_CHICK             Reviewed;         211 AA.
AC   P55165;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 3.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Beta-crystallin B3;
DE   AltName: Full=Beta-B3 crystallin;
GN   Name=CRYBB3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Lens;
RX   PubMed=8674507; DOI=10.1006/exer.1996.0013;
RA   Duncan M.K., Banerjee-Basu S., McDermott J.B., Piatigorsky J.;
RT   "Sequence and expression of chicken beta A2- and beta B3-crystallins.";
RL   Exp. Eye Res. 62:111-119(1996).
RN   [2]
RP   SEQUENCE REVISION TO 17-20; 44; 141 AND 166.
RA   Duncan M.K.;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U28146; AAB08775.2; -; mRNA.
DR   RefSeq; NP_990522.1; NM_205191.1.
DR   AlphaFoldDB; P55165; -.
DR   SMR; P55165; -.
DR   STRING; 9031.ENSGALP00000037858; -.
DR   Ensembl; ENSGALT00000038650; ENSGALP00000037858; ENSGALG00000005515.
DR   GeneID; 396108; -.
DR   KEGG; gga:396108; -.
DR   CTD; 1417; -.
DR   VEuPathDB; HostDB:geneid_396108; -.
DR   eggNOG; ENOG502QTNZ; Eukaryota.
DR   GeneTree; ENSGT00940000158425; -.
DR   HOGENOM; CLU_081883_0_1_1; -.
DR   InParanoid; P55165; -.
DR   OMA; NEWNASQ; -.
DR   OrthoDB; 1237607at2759; -.
DR   PhylomeDB; P55165; -.
DR   PRO; PR:P55165; -.
DR   Proteomes; UP000000539; Chromosome 15.
DR   Bgee; ENSGALG00000005515; Expressed in lung and 6 other tissues.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR033115; CRYBB3.
DR   InterPro; IPR011024; G_crystallin-like.
DR   PANTHER; PTHR11818:SF13; PTHR11818:SF13; 1.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..211
FT                   /note="Beta-crystallin B3"
FT                   /id="PRO_0000057563"
FT   DOMAIN          24..63
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          64..108
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          114..155
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          156..198
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          1..23
FT                   /note="N-terminal arm"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..113
FT                   /note="Connecting peptide"
FT   REGION          200..211
FT                   /note="C-terminal arm"
SQ   SEQUENCE   211 AA;  24450 MW;  FB2DF1225314D2E3 CRC64;
     MTEQQSPPEQ MVTGEGAGER GGNYKITIYE LENFQGRRCE LSEELPNVVD KALEKVGSIQ
     VESGPWLGFE RQAFAGEQFV LEKGDYPRWD SWSNSHNSDS LMSLRPLQID SPDHKIHLFE
     NAGYTGRKME IVDDDVPSLW AHGFQDRVAS VRALNGTWVG YEYPGYRGRQ HVFEKGEYRH
     WNEWDANQPL MQSVRRVRDQ QWHQRGSFEN S