CRBG2_HUMAN
ID CRBG2_HUMAN Reviewed; 1661 AA.
AC Q8N1P7; B2RNG3; Q5T137; Q5T150;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-FEB-2019, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Beta/gamma crystallin domain-containing protein 2 {ECO:0000312|HGNC:HGNC:17295};
DE AltName: Full=Absent in melanoma 1-like protein;
GN Name=CRYBG2 {ECO:0000312|HGNC:HGNC:17295}; Synonyms=AIM1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 937-1661.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1037-1661.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI36871.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC04533.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL451139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK095339; BAC04533.1; ALT_INIT; mRNA.
DR EMBL; BC136870; AAI36871.1; ALT_INIT; mRNA.
DR RefSeq; NP_001034864.2; NM_001039775.3.
DR RefSeq; XP_005245975.1; XM_005245918.2.
DR AlphaFoldDB; Q8N1P7; -.
DR SMR; Q8N1P7; -.
DR BioGRID; 120378; 28.
DR STRING; 9606.ENSP00000310435; -.
DR CAZy; CBM13; Carbohydrate-Binding Module Family 13.
DR iPTMnet; Q8N1P7; -.
DR PhosphoSitePlus; Q8N1P7; -.
DR BioMuta; CRYBG2; -.
DR DMDM; 74750904; -.
DR EPD; Q8N1P7; -.
DR jPOST; Q8N1P7; -.
DR MassIVE; Q8N1P7; -.
DR MaxQB; Q8N1P7; -.
DR PaxDb; Q8N1P7; -.
DR PeptideAtlas; Q8N1P7; -.
DR PRIDE; Q8N1P7; -.
DR ProteomicsDB; 71626; -.
DR Antibodypedia; 30616; 115 antibodies from 17 providers.
DR DNASU; 55057; -.
DR Ensembl; ENST00000308182.10; ENSP00000310435.6; ENSG00000176092.17.
DR GeneID; 55057; -.
DR KEGG; hsa:55057; -.
DR MANE-Select; ENST00000308182.10; ENSP00000310435.6; NM_001039775.4; NP_001034864.2.
DR UCSC; uc001bmd.4; human.
DR CTD; 55057; -.
DR DisGeNET; 55057; -.
DR GeneCards; CRYBG2; -.
DR HGNC; HGNC:17295; CRYBG2.
DR HPA; ENSG00000176092; Tissue enhanced (esophagus, skin, vagina).
DR MIM; 619765; gene.
DR neXtProt; NX_Q8N1P7; -.
DR OpenTargets; ENSG00000176092; -.
DR PharmGKB; PA24650; -.
DR VEuPathDB; HostDB:ENSG00000176092; -.
DR eggNOG; ENOG502R2J7; Eukaryota.
DR GeneTree; ENSGT00940000157740; -.
DR HOGENOM; CLU_002147_0_1_1; -.
DR InParanoid; Q8N1P7; -.
DR OrthoDB; 89929at2759; -.
DR PhylomeDB; Q8N1P7; -.
DR PathwayCommons; Q8N1P7; -.
DR BioGRID-ORCS; 55057; 6 hits in 250 CRISPR screens.
DR ChiTaRS; AIM1L; human.
DR GenomeRNAi; 55057; -.
DR Pharos; Q8N1P7; Tdark.
DR PRO; PR:Q8N1P7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N1P7; protein.
DR Bgee; ENSG00000176092; Expressed in lower esophagus mucosa and 160 other tissues.
DR ExpressionAtlas; Q8N1P7; baseline and differential.
DR Genevisible; Q8N1P7; HS.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR Pfam; PF00030; Crystall; 6.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00458; RICIN; 1.
DR SMART; SM00247; XTALbg; 6.
DR SUPFAM; SSF49695; SSF49695; 3.
DR SUPFAM; SSF50370; SSF50370; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 12.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 2: Evidence at transcript level;
KW Lectin; Reference proteome; Repeat.
FT CHAIN 1..1661
FT /note="Beta/gamma crystallin domain-containing protein 2"
FT /id="PRO_0000285105"
FT DOMAIN 986..1023
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1024..1067
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1073..1113
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1114..1156
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1168..1213
FT /note="Beta/gamma crystallin 'Greek key' 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1214..1256
FT /note="Beta/gamma crystallin 'Greek key' 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1262..1302
FT /note="Beta/gamma crystallin 'Greek key' 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1303..1345
FT /note="Beta/gamma crystallin 'Greek key' 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1356..1393
FT /note="Beta/gamma crystallin 'Greek key' 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1394..1437
FT /note="Beta/gamma crystallin 'Greek key' 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1443..1483
FT /note="Beta/gamma crystallin 'Greek key' 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1484..1525
FT /note="Beta/gamma crystallin 'Greek key' 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 1569..1659
FT /note="Ricin B-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT REGION 72..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..838
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 1294
FT /note="S -> N (in dbSNP:rs10751735)"
FT /id="VAR_048835"
SQ SEQUENCE 1661 AA; 177913 MW; D35FF16D993D8071 CRC64;
MEEAGGPMAR AKARVVSATL TWRQRPPTQE EIKHGFHKVS LVSGAQMEAP QKEMFEFSRR
EEVEVNGFAT QEEETVNCQG PRDTAGSKNF QSHGPIFSKK YIPPPKEKRP EGRLKEAVDQ
SDGSRQAPRT EPPCVGAMAR TELLVPLPGP REPSPHPGVG LTSGSSRSLE EYRVTRTVRT
TTVVGGHVDR RMSSSVTVRP VSSGEALPRG RQVSRMVPPV VVGSPPGSPS RSQAVKVLSN
LVPAGHSPPA SHLPRPTAGG PRSTGLGSTV GAALRQLPET GTAELKDSSA LASTGIPASA
HLPKNQDAPA ACPDRDQGRA PDARACELWQ VLGAPSSTEL PLQTSQGQAS VPSSPRLETH
VPSPGLTHPA KQPVVPTHPG ARLTPLVLPP KKKDGPVDPP AATVLPMVRS EHVTVPGQPP
APSTTRRKDV PSPGGLSAPS SPRNKFVQNS ENVPVLPFTQ REVVKGPGAP AASSPTRKEV
VQGSSASAAS SPTWKEVVKG PGAPAASSPT QKEVVQGSSA PAALFPTWKE VVKGPGAPDA
SFPTWKEVVK GPGAPAASSP TQKEVVQGSG APAALSTTPK EVVKGPGAPA ASSPTQKEVV
KGPCAPAASS PTQKEVVQGS GAPAALSPKS TEVVQGPKGS SSIQKEAVQG IAGSLAPPLT
KEETVQGPIA PATSLPKQDK GVQDSEGSPI SSLTQKEVVQ DPDALPAPSS SVDRVSPSPG
GTPAPVPTGA EASTESQLVS DPTEGKTCTE TSREEDEVAL AADLEIFLDT LRSMEPPEIL
RTHRLPRAPR SSYLSMYATL PAIEEDQLGP WVLGPGPQEV PSLEEKEEEE EEEPENPYLS
DDEKLQRRQE KAGPSPSRDL HPARPTQVSC SPLEMMKKHV AGTKGPHSEL GLELQGGSRP
TSRLGGSLLF GSLVPTAKEA STPEPLGTKL SALLPHGAPG LRKVPGQLPL LCSERSSPTE
KLACSLPLEG WSPALKTQGK LNTRPGKVIF FSESGCQGSG REVWGDIVDA SGWAPVASIR
VVRGCWVLYE EPEFRGQKLV LPEGDMELRT PGTKWSPQGI GSLRRVVWDY STPEISLFSE
EGLKGEQVKL TEALKNSQGL EKPLQVASAT VSAGLWLLYP KPLFEDTPYI LEPGEYPTSE
AWGTSDPSVG SLKPMRLGCP SVEKPGEPRA VVYEAPGFQG RSWEVSRDIY NLQQPEDSQS
PHLASVGSLR VLGGCWVGYE KEGFRGHQYL LEEGEYPDWS HWGGYDELLT SLRVIRTDFG
DPAVVLFEAM DFEGHGVEVS KALPDVELVQ HGPSTQAIHV LSGVWVAYQE VGFSGEQYVL
EKGVYRNCED WGAGNSTLAS LQPVLQVGEH DLHFVSKIQL FSRPDFLGDH FSFEDDQAAL
PASFRPQSCR VHGGSWILFD ETNFEGDQHI LSEGEFPTLT AMGCLASTVL GSLQKVSLHF
SEPSIFLYGL ECFEGKEIEL SREVRSLQAE GFNNHVLSVR IKGGIWVLCE HSDFRGRQWL
VGSCEITNWL TYSGTQRVGS LYPIKQRRVY FRLWNAALGG FLAVPDHVED MKAGRVVVAD
PQAGGSCIWY YEDGLLKNQM APTMSLQVIG PPSPGSKVVL WAESRLPRQT WSISESGHIC
SQMFEGQILD VKGGRGYDRD HVVLWEPDED RASQIWTIHV L
