ID   CRBL2_DANRE             Reviewed;         119 AA.
AC   Q642H2; Q6DH72;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=cAMP-responsive element-binding protein-like 2;
GN   Name=crebl2; ORFNames=zgc:92620;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable regulator of creb1 transcriptional activity which is
CC       involved in adipose cells differentiation. May also play a regulatory
CC       role in the cell cycle (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q642H2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q642H2-2; Sequence=VSP_031181;
CC   -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily. {ECO:0000305}.
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DR   EMBL; BC076109; AAH76109.1; -; mRNA.
DR   EMBL; BC081675; AAH81675.1; -; mRNA.
DR   RefSeq; NP_001002702.2; NM_001002702.2. [Q642H2-1]
DR   RefSeq; XP_005168555.1; XM_005168498.3. [Q642H2-1]
DR   AlphaFoldDB; Q642H2; -.
DR   SMR; Q642H2; -.
DR   STRING; 7955.ENSDARP00000113878; -.
DR   PaxDb; Q642H2; -.
DR   Ensembl; ENSDART00000172255; ENSDARP00000137889; ENSDARG00000104049. [Q642H2-1]
DR   Ensembl; ENSDART00000186461; ENSDARP00000155966; ENSDARG00000104049. [Q642H2-2]
DR   GeneID; 436975; -.
DR   KEGG; dre:436975; -.
DR   CTD; 1389; -.
DR   ZFIN; ZDB-GENE-040718-456; crebl2.
DR   eggNOG; KOG4515; Eukaryota.
DR   GeneTree; ENSGT00390000005388; -.
DR   HOGENOM; CLU_134161_0_0_1; -.
DR   InParanoid; Q642H2; -.
DR   OMA; DQGRMPE; -.
DR   OrthoDB; 1551209at2759; -.
DR   PhylomeDB; Q642H2; -.
DR   PRO; PR:Q642H2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 4.
DR   Bgee; ENSDARG00000104049; Expressed in brain and 22 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0045600; P:positive regulation of fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
DR   GO; GO:0046889; P:positive regulation of lipid biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR039250; CREBL2/REPTOR-BP.
DR   PANTHER; PTHR21051; PTHR21051; 1.
DR   Pfam; PF07716; bZIP_2; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
PE   3: Inferred from homology;
KW   Activator; Alternative splicing; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..119
FT                   /note="cAMP-responsive element-binding protein-like 2"
FT                   /id="PRO_0000318195"
FT   DOMAIN          23..86
FT                   /note="bZIP"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          29..60
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000250"
FT   REGION          62..69
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000250"
FT   REGION          95..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..70
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_031181"
SQ   SEQUENCE   119 AA;  13525 MW;  190BDBFDFAF4C67E CRC64;
     MDDSKIVAGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY LEELVSSKER
     AICALREELD MYKQWCLAMD QGKIPSEIKA LLTGDEQKTP QSCSNKTTKN SKYSSSSGI