ID   CRBL2_RAT               Reviewed;         123 AA.
AC   Q5BJU6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=cAMP-responsive element-binding protein-like 2;
GN   Name=Crebl2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable regulator of CREB1 transcriptional activity which is
CC       involved in adipose cells differentiation. May also play a regulatory
CC       role in the cell cycle (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CREB1; regulates CREB1 phosphorylation,
CC       stability and transcriptional activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated by AMPK. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily. {ECO:0000305}.
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DR   EMBL; BC091323; AAH91323.1; -; mRNA.
DR   RefSeq; NP_001015027.1; NM_001015027.1.
DR   AlphaFoldDB; Q5BJU6; -.
DR   SMR; Q5BJU6; -.
DR   STRING; 10116.ENSRNOP00000009324; -.
DR   PaxDb; Q5BJU6; -.
DR   Ensembl; ENSRNOT00000119142; ENSRNOP00000094879; ENSRNOG00000067300.
DR   GeneID; 362453; -.
DR   KEGG; rno:362453; -.
DR   UCSC; RGD:1309502; rat.
DR   CTD; 1389; -.
DR   RGD; 1309502; Crebl2.
DR   eggNOG; KOG4515; Eukaryota.
DR   GeneTree; ENSGT00390000005388; -.
DR   InParanoid; Q5BJU6; -.
DR   OrthoDB; 1551209at2759; -.
DR   PhylomeDB; Q5BJU6; -.
DR   TreeFam; TF323305; -.
DR   PRO; PR:Q5BJU6; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0045600; P:positive regulation of fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
DR   GO; GO:0046889; P:positive regulation of lipid biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR039250; CREBL2/REPTOR-BP.
DR   PANTHER; PTHR21051; PTHR21051; 1.
DR   Pfam; PF07716; bZIP_2; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
PE   2: Evidence at transcript level;
KW   Activator; Differentiation; DNA-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..123
FT                   /note="cAMP-responsive element-binding protein-like 2"
FT                   /id="PRO_0000318194"
FT   DOMAIN          23..86
FT                   /note="bZIP"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          29..60
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000250"
FT   REGION          62..69
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000250"
FT   REGION          93..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   123 AA;  14019 MW;  F1978A47A582D62C CRC64;
     MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY LEELVSSRER
     AICALREELE MYKQWCMAMD QGKIPSEIRA LLTGEEQNKS QQNSSRHPKA GKTDANTNSL
     VGN