ID   CRBL2_XENTR             Reviewed;         118 AA.
AC   A4IGK3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=cAMP-responsive element-binding protein-like 2;
GN   Name=crebl2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable regulator of creb1 transcriptional activity which is
CC       involved in adipose cells differentiation. May also play a regulatory
CC       role in the cell cycle (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily. {ECO:0000305}.
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DR   EMBL; BC135139; AAI35140.1; -; mRNA.
DR   RefSeq; NP_001090852.1; NM_001097383.1.
DR   AlphaFoldDB; A4IGK3; -.
DR   SMR; A4IGK3; -.
DR   STRING; 8364.ENSXETP00000058036; -.
DR   PaxDb; A4IGK3; -.
DR   DNASU; 100038265; -.
DR   Ensembl; ENSXETT00000058036; ENSXETP00000058036; ENSXETG00000027934.
DR   GeneID; 100038265; -.
DR   KEGG; xtr:100038265; -.
DR   CTD; 1389; -.
DR   Xenbase; XB-GENE-940117; crebl2.
DR   eggNOG; KOG4515; Eukaryota.
DR   HOGENOM; CLU_134161_0_0_1; -.
DR   InParanoid; A4IGK3; -.
DR   OMA; DQGRMPE; -.
DR   OrthoDB; 1551209at2759; -.
DR   PhylomeDB; A4IGK3; -.
DR   TreeFam; TF323305; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027934; Expressed in testis and 12 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0045600; P:positive regulation of fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
DR   GO; GO:0046889; P:positive regulation of lipid biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR039250; CREBL2/REPTOR-BP.
DR   PANTHER; PTHR21051; PTHR21051; 1.
DR   Pfam; PF07716; bZIP_2; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
PE   3: Inferred from homology;
KW   Activator; Differentiation; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..118
FT                   /note="cAMP-responsive element-binding protein-like 2"
FT                   /id="PRO_0000318196"
FT   DOMAIN          23..86
FT                   /note="bZIP"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          29..60
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000250"
FT   REGION          62..69
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   118 AA;  13513 MW;  768FC0072AA8FEEF CRC64;
     MDDSKVSGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY LEELVSSRER
     AICALREELE MYKQWCAAMD QGKIPSEIKA LLSGEDLKAA PNQVKHRAVK TEQKEKCP